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Gout
Sudden, very painful flares in a joint — often the big toe — caused by crystals of uric acid. Gout affects about 9 million U.S. adults. With the right diagnosis, medicine that lowers uric acid and steady daily habits, it is one of the most controllable kinds of arthritis.
Get medical care the same day — urgent care or an emergency department — for any of these:
- A hot, swollen, painful joint with fever or chills. It could be a joint infection (septic arthritis), which comes on quickly with intense swelling, pain, fever and chills and can quickly and permanently damage a joint (Arthritis Foundation (opens in a new tab)). Sudden joint pain and swelling that is getting worse, or comes with a very high temperature, shivering or feeling sick, may mean an infection inside the joint that needs urgent help (NHS (opens in a new tab)).
- Your first-ever sudden hot, swollen joint. Gout can look like other diseases, so a doctor should diagnose it, and early diagnosis lets you start treatment quickly (CDC (opens in a new tab)). Your doctor will want to rule out infection, injury or another type of arthritis (Arthritis Foundation (opens in a new tab)), and may test fluid from the joint for crystals (American College of Rheumatology (opens in a new tab)).
- Signs of a kidney stone with fever. Severe pain in your side, back, belly or groin with a high temperature or shivering needs urgent care (NHS (opens in a new tab)). Fever and chills, blood in the urine, vomiting, or back or side pain that won’t go away are signs a stone needs a doctor’s help (MedlinePlus (opens in a new tab), NIDDK (opens in a new tab)).
Don’t wait for a chiropractic, acupuncture or massage appointment, and never have a hot, swollen joint massaged or manipulated.
What is gout?
Gout is a type of inflammatory arthritis that causes pain and swelling in the joints, usually as flares that last a week or two and then settle (NIAMS (opens in a new tab)). It is the most common type of inflammatory arthritis (Arthritis Foundation (opens in a new tab)).
It starts with uric acid (urate), a waste product your body makes when it breaks down purines from its own tissues and from many foods. The kidneys normally filter it out into the urine; if your body makes too much or removes too little, it builds up in the blood (MedlinePlus (opens in a new tab)). Over time, high levels can form needle-shaped crystals in and around a joint, causing inflammation — though many people with high uric acid never get gout (NIAMS (opens in a new tab)).
How common is it?
In a national U.S. health survey for 2015–2016, 3.9% of U.S. adults — about 9.2 million people — had gout: 5.2% of men and 2.7% of women. Only about a third of people with gout were taking medicine to lower uric acid (Chen-Xu et al., 2019 (opens in a new tab)).
Sudden, painful flares
Many people have their first flare in a big toe. Flares often start suddenly at night, with pain bad enough to wake you, and the joint may be swollen, red and warm (NIAMS (opens in a new tab)). Gout can also strike other toes, the ankle or the knee (MedlinePlus (opens in a new tab)), usually one joint at a time (CDC (opens in a new tab)). Attacks usually peak after 12 to 24 hours (Arthritis Foundation (opens in a new tab)). Between flares you usually feel fine, but untreated flares may come more often and last longer. Foods, alcohol, some medicines, injury or illness can set them off (NIAMS (opens in a new tab)). See our feet guide for other causes of foot pain.
Who gets gout?
- Men are about three times more likely than women to get it; it tends to start after 40 in men and after menopause in women (Arthritis Foundation (opens in a new tab)).
- Genes and family history play a part (NIAMS (opens in a new tab)).
- Kidney disease, high blood pressure, heart failure, metabolic syndrome and obesity (MedlinePlus (opens in a new tab)), and diabetes (CDC (opens in a new tab)).
- Certain medicines, such as diuretics (water pills), low-dose aspirin, some immune-suppressing medicines and large amounts of niacin (MedlinePlus (opens in a new tab)). Never stop a prescribed medicine on your own.
- Alcohol, especially beer (ACR (opens in a new tab)), sugary drinks with high-fructose corn syrup (ACR (opens in a new tab)), and purine-rich foods such as red meat, organ meats and some seafood (CDC (opens in a new tab)).
Tophi and kidney stones
Untreated for years, crystals can build into hard lumps called tophi under the skin and in and around joints. They start painless but can become painful and damage bone and joints; proper treatment can prevent them (NIAMS (opens in a new tab)). They often sit over a joint or on the outer ear (ACR (opens in a new tab)). Uric acid crystals can also form kidney stones, and uric acid–lowering medicine helps prevent both (MedlinePlus (opens in a new tab)).
Links with heart and kidney disease
People with gout are more likely to have high blood pressure, chronic kidney disease, obesity, diabetes, kidney stones, heart attack and heart failure (NIAMS (opens in a new tab)), so your provider may check for these (ACR (opens in a new tab)). High uric acid can also lead to kidney failure (MedlinePlus (opens in a new tab)). See our blood pressure and diabetes guides; MBHA guides to the kidneys and the heart are on the way.
How it’s diagnosed
- Joint fluid: finding uric acid crystals in fluid drawn from the joint is the best way to diagnose gout (Arthritis Foundation (opens in a new tab)). It is easiest during a flare (CDC (opens in a new tab)).
- Uric acid blood test: high levels don’t always mean gout (ACR (opens in a new tab)), and some people with gout have normal levels (Arthritis Foundation (opens in a new tab)). In one small study, levels were lower during a flare than two weeks later (Zhang et al., 2023 (opens in a new tab)), so a normal result during a flare doesn’t rule gout out.
- Imaging: X-rays, ultrasound, MRI, or dual-energy CT, which helps show uric acid crystals (Arthritis Foundation (opens in a new tab)).
Red, hot, swollen skin can also be an infection called cellulitis (NHS (opens in a new tab)) — see our cellulitis guide. Most people with gout are cared for by their primary care provider (NIAMS (opens in a new tab)).
Pseudogout (CPPD) is different
Calcium pyrophosphate deposition (CPPD), once called “pseudogout,” comes from calcium pyrophosphate crystals, not uric acid. It causes severe pain, warmth and swelling, most often in the knees, and is more common after 60; there is no treatment yet that dissolves its crystals (ACR (opens in a new tab)). See our arthritis guide for other types.
Side by side
Six approaches compared
For every condition we look at the same six approaches: what each involves, what it typically costs, and what a patient can realistically expect.
| Approach | What it involves | Estimated cost | What to expect |
|---|---|---|---|
| Conventional medicine (AMA) | NSAIDs, colchicine or corticosteroids for flares; for frequent flares, tophi or kidney stones, daily urate-lowering medicine — allopurinol first — adjusted to a uric acid target, with preventive medicine at the start. | Cost estimate being researched. | Flare medicine should start working within 2 days. Taken steadily, urate-lowering medicine prevents flares and tophi; many people become flare-free. |
| Chiropractic | No role in treating gout or its flares. Never have an inflamed joint manipulated. | Not applicable to gout care. | We found little research on chiropractic care for gout. |
| Acupuncture | Needle or electroacupuncture sessions, studied mainly for acute flares. | About $125–$230 for a first private visit and $90–$185 for follow-ups; community clinics about $50–$90. | Reviews of mostly small trials from China report benefits, but the evidence is low or very low quality. Not a substitute for medicine. |
| Herbal medicine | Cherries or cherry extract, vitamin C and coffee are the most studied; celery seed is widely promoted. | Cost estimate being researched. | Mostly observational or weak evidence; the ACR guideline advises against adding vitamin C. No supplement replaces urate-lowering medicine. |
| Massage therapy | Gentle massage of other areas for comfort — never on a flaring joint. | About $60–$120 for 45–60 minutes with a private therapist, or $50–$90 at clinics, gyms and spas. | A comfort measure only; we found little research on massage for gout. |
| MBHA Wellness Coach | Food and drink changes, weight loss, fluids, taking medicine every day, a flare plan, flare footwear, and tracking blood pressure and kidney health. | Cost estimate being researched. | Supports — never replaces — medical care. Habits help, but medicine is the mainstay when flares are frequent or tophi are present. |
Approach 1 of 6
Conventional medicine (AMA)
Treatment has two jobs: calm each flare quickly, and lower uric acid over the long term so flares, tophi and joint damage stop (NIAMS (opens in a new tab)). U.S. care follows the 2020 American College of Rheumatology (ACR) guideline (ACR guideline, 2020 (opens in a new tab)).
1. Treating a flare
The guideline strongly recommends colchicine, NSAIDs (anti-inflammatory pain relievers) or corticosteroids (by mouth or by injection), chosen to suit the person; an IL-1 blocker is an option if these can’t be used (ACR guideline, 2020 (opens in a new tab)). Colchicine works best when taken as symptoms first appear (NIAMS (opens in a new tab)). NSAIDs can cause stomach ulcers and bleeding, and colchicine can cause nausea or diarrhea (Arthritis Foundation (opens in a new tab)).
2. Who needs urate-lowering therapy (ULT)?
The guideline strongly recommends daily ULT for people with tophi, joint damage from gout on imaging, or frequent flares (two or more a year). It conditionally recommends it for less frequent flares, and after a first flare in people with moderate or worse kidney disease, very high uric acid or kidney stones (ACR guideline, 2020 (opens in a new tab)).
3. The medicines
- Allopurinol is the strongly preferred first choice, including for people with kidney disease, started low and raised step by step (ACR guideline, 2020 (opens in a new tab)). Febuxostat also blocks uric acid production; probenecid helps the kidneys remove it; pegloticase infusions break it down (ACR (opens in a new tab)) and are not a first choice (ACR guideline, 2020 (opens in a new tab)).
- HLA-B*5801 testing. This gene variant greatly raises the risk of a serious allergic reaction to allopurinol. The guideline conditionally recommends testing before allopurinol for people of Southeast Asian descent (such as Han Chinese, Korean or Thai) and African American people, who carry it more often (ACR guideline, 2020 (opens in a new tab)). On allopurinol, stop it and call your doctor or get emergency care for a rash, peeling or blistering skin, lip or mouth swelling, or fever (MedlinePlus (opens in a new tab)).
- Febuxostat’s boxed warning. In a heart-safety study, gout patients with heart disease taking febuxostat had a higher rate of heart-related death than those taking allopurinol, so its FDA label limits it to people for whom allopurinol hasn’t worked well enough, isn’t tolerated or isn’t advisable (FDA-approved label, DailyMed (opens in a new tab), CARES trial, 2018 (opens in a new tab)). The guideline suggests switching medicines for people on febuxostat who have heart disease or a new heart event (ACR guideline, 2020 (opens in a new tab)). If you take it, call your doctor right away for chest pain, shortness of breath, a racing or irregular heartbeat, or weakness on one side (MedlinePlus (opens in a new tab)).
4. Treat to target, with protection at the start
- The guideline strongly recommends adjusting ULT with regular blood tests until uric acid stays below 6 mg/dL, and suggests continuing it indefinitely (ACR guideline, 2020 (opens in a new tab), ACR (opens in a new tab)).
- Because flares can increase in the first months (MedlinePlus (opens in a new tab)), it strongly recommends a preventive anti-inflammatory medicine for at least three to six months (ACR guideline, 2020 (opens in a new tab)).
- Don’t stop ULT because of a flare. The febuxostat label says it need not be stopped during a flare (FDA-approved label, DailyMed (opens in a new tab)), and allopurinol shouldn’t be stopped without talking to your doctor (MedlinePlus (opens in a new tab)). Extra attacks early on are a sign the medicine is working (Arthritis UK (opens in a new tab)).
We don’t list doses; your doctor will tailor any medicine to you.
5. Your other medicines
Where practical, the guideline suggests switching from the diuretic hydrochlorothiazide to another blood pressure medicine, but not stopping low-dose aspirin taken for a good reason (ACR guideline, 2020 (opens in a new tab)). Talk with your doctor before changing any medicine (NIAMS (opens in a new tab)); see our blood pressure guide.
What it costs
Gout medicines and tests: MBHA cost estimate being researched.
What to expect
With early diagnosis, treatment and lifestyle changes, gout is one of the most controllable forms of arthritis, and some people become gout-free (NIAMS (opens in a new tab)). With frequent flares or tophi, taking ULT regularly is the key (NIAMS (opens in a new tab)).
Approach 2 of 6
Chiropractic
Chiropractic care has no role in treating gout or a gout flare; the proven treatments are medicines (ACR guideline, 2020 (opens in a new tab)). We found little research on chiropractic care for gout — mainly a review urging chiropractors to recognize the uncommon cases where gout affects the spine (McConville and Cox, 2023 (opens in a new tab)).
MBHA caution: never have a hot, swollen or flaring joint manipulated or pressed. Pressure can make the pain worse (NHS (opens in a new tab)), and the joint may be infected (see the alert above). Serious problems after spinal manipulation are very rare but may be more likely with underlying health problems (NCCIH (opens in a new tab)).
Approach 3 of 6
Acupuncture
Acupuncture has been studied for gout flares, mostly in small trials in China, alone or added to standard medicine. The reviews sound positive, but the trials are generally low quality.
- A 2013 review of 10 trials (852 people) found most reported lower uric acid or less pain, and called for rigorous trials (Lee et al., 2013 (opens in a new tab)).
- A 2016 review of 28 trials (2,237 people) reported benefits over standard drugs but warned they “might be overstated” because of weak study methods (Lu et al., 2016 (opens in a new tab)).
- A 2024 review of 15 single-center trials of electroacupuncture, all in China, rated the evidence for pain relief very low; only one trial blinded its assessors (Ni et al., 2024 (opens in a new tab)). Another 2024 analysis of 32 trials judged the evidence poor (Fan et al., 2024 (opens in a new tab)).
Acupuncture may add comfort, but it hasn’t been shown to replace flare medicine or the long-term work of lowering uric acid.
Safety and cost
Few complications have been reported; problems have come from non-sterile needles and poor technique, and U.S. needles must be sterile and single-use (NCCIH (opens in a new tab)). MBHA suggests ruling out a joint infection first and keeping needles out of a hot, swollen joint. Visits run about $125–$230 for a first private visit and $90–$185 for follow-ups, or about $50–$90 at community clinics (The Pricer (opens in a new tab)).
Approach 4 of 6
Herbal medicine
No food or supplement replaces urate-lowering medicine. A 2025 review of trials of cherry products, vitamin C, fish oil and Chinese herbal formulas found mixed, often contradictory results (Pardali et al., 2025 (opens in a new tab)), and a Cochrane review found no high-quality evidence for or against the supplements it assessed (Cochrane review, 2021 (opens in a new tab)).
- Cherries: among 633 people with gout, eating cherries over two days was linked with a 35% lower risk of a flare, and cherry extract showed a similar link (Zhang et al., 2012 (opens in a new tab)). This was observational, not a trial; the ACR guideline rated the evidence low or very low and made no recommendation (ACR guideline, 2020 (opens in a new tab)).
- Vitamin C: supplements lowered uric acid slightly in a pooled analysis of 13 trials (Juraschek et al., 2011 (opens in a new tab)), and higher vitamin C intake was linked with less gout in a long study of men (Choi et al., 2009 (opens in a new tab)). But in 40 people with gout the effect was not clinically meaningful and far smaller than allopurinol’s (Stamp et al., 2013 (opens in a new tab)). The ACR guideline advises against adding vitamin C (ACR guideline, 2020 (opens in a new tab)).
- Coffee: large long-term studies linked more coffee with a lower chance of developing gout in men and women (Choi et al., 2007 (opens in a new tab), Choi and Curhan, 2010 (opens in a new tab)) — an association, not proof it treats gout.
- Celery seed: we found little research — studies in rodents (Li et al., 2019 (opens in a new tab)) and one small trial in people with metabolic syndrome, not gout (Escobedo-Gutiérrez et al., 2026 (opens in a new tab)), and no good evidence it helps gout.
- Avoid high-fructose drinks: the ACR guideline suggests limiting high-fructose corn syrup (ACR guideline, 2020 (opens in a new tab)).
Before you take any supplement, show it to your doctor or pharmacist: supplements may interact with your medicines or pose risks with some health problems (NCCIH (opens in a new tab)). Never swap a gout medicine for a supplement. We don’t list doses here.
Approach 5 of 6
Massage therapy
Massage doesn’t treat gout, and we found little research on it. Don’t massage a flaring joint: pressure can make the pain worse (NHS (opens in a new tab)), and a hot, swollen joint could be infected. Gentle massage elsewhere — back, neck or shoulders — may help you relax while you recover; tell your therapist you have gout. Don’t use massage to put off seeing a provider; rare serious side effects have been reported (NCCIH (opens in a new tab)).
What it costs
About $60–$120 for 45–60 minutes with a private therapist, or $50–$90 at clinics, gyms and spas (CostHelper (opens in a new tab)).
Approach 6 of 6
MBHA Wellness Coach
An MBHA Wellness Coach helps you turn your care plan into daily habits — alongside, never instead of, medical care. Genes play a big part in gout, and the ACR guideline’s authors caution that diet advice should never feel like blame (ACR guideline, 2020 (opens in a new tab)).
Food and drink
The guideline conditionally recommends limiting alcohol, purine-rich foods and high-fructose corn syrup (ACR guideline, 2020 (opens in a new tab)). Your coach can help you find swaps you’ll keep (see Food and drink).
Weight, activity and fluids
For people with overweight, the guideline suggests weight loss (ACR guideline, 2020 (opens in a new tab)), which helps reduce uric acid and flares (NIAMS (opens in a new tab)); avoid crash diets (NHS (opens in a new tab)). Aim for 150 minutes a week of moderate activity (CDC (opens in a new tab)). Drink plenty of fluids (NHS (opens in a new tab)) — water also helps prevent kidney stones (NIDDK (opens in a new tab)) — unless you have kidney failure or are on dialysis and your team limits fluids (see our dialysis guide). An MBHA weight control guide is on the way.
Taking medicine every day
Taking ULT regularly is the key to preventing flares (NIAMS (opens in a new tab)), even when you feel well (NHS (opens in a new tab)). A coach can help with reminders, refills and a log of your uric acid results.
A flare action plan
Plan ahead with your doctor. The guideline’s patient panel favored keeping flare medicine on hand for the first signs (ACR guideline, 2020 (opens in a new tab)), since flare medicines work best when started early (Arthritis UK (opens in a new tab)). Write down what to take, the steps in During a flare, who to call and the warning signs at the top of this page.
Footwear during flares
Keep pressure and bedclothes off the sore joint (NHS (opens in a new tab)). MBHA suggests soft, roomy shoes or open-toed sandals that don’t press on the big toe while it flares.
Blood pressure and kidney health
Because gout travels with high blood pressure, heart and kidney disease (ACR (opens in a new tab)), keep up with blood pressure and kidney checks. The DASH eating plan can help lower blood pressure and may lower uric acid (NIAMS (opens in a new tab)); see our blood pressure and diabetes guides.
Another approach
During a flare: what helps
First check the alert at the top of this page. Then:
- Take your prescribed flare medicine as soon as possible; it should start to work within 2 days (NHS (opens in a new tab)).
- Keep taking your urate-lowering medicine unless your doctor says otherwise (FDA-approved label, DailyMed (opens in a new tab), MedlinePlus (opens in a new tab)).
- Ice wrapped in a towel, up to 20 minutes at a time (NHS (opens in a new tab)); the ACR guideline supports ice alongside medicine (ACR guideline, 2020 (opens in a new tab)).
- Rest and raise the joint (NIAMS (opens in a new tab)), and drink lots of water unless a doctor has told you not to (NHS (opens in a new tab)).
- Protect the joint: no pressure on it, and keep bedclothes off it at night (NHS (opens in a new tab)).
An untreated attack usually lasts 1 to 2 weeks. See a doctor if your usual treatment isn’t helping (NHS (opens in a new tab)).
Another approach
Long-term: lowering uric acid
Flare medicines calm the fire; urate-lowering medicine removes the fuel, stopping new crystals and dissolving old ones. Clearing them can take months or years, but once they’re gone, attacks and tophi stop (Arthritis UK (opens in a new tab)). Know your number — the goal is below 6 mg/dL (ACR guideline, 2020 (opens in a new tab)) — expect a bumpy first few months, and plan to stay on treatment (see conventional medicine).
Another approach
Food and drink
Diet usually changes uric acid only a little, but food and drink may trigger flares (ACR guideline, 2020 (opens in a new tab)).
- Alcohol: more than one or two drinks in the previous 24 hours was linked with a 40% higher flare risk in research the ACR guideline reviewed (ACR guideline, 2020 (opens in a new tab)). Beer is a particular concern (ACR (opens in a new tab)), and NIAMS’s advice to cut back includes nonalcoholic beer (NIAMS (opens in a new tab)).
- Purine-rich foods: red meat, organ meats (NIAMS (opens in a new tab)) and seafood such as anchovies, sardines, mussels, scallops, trout and tuna (CDC (opens in a new tab)). Fish’s heart benefits likely outweigh its gout risk (Arthritis Foundation (opens in a new tab)), so ask a dietitian about balance.
- Sugary drinks: limit high-fructose corn syrup (ACR guideline, 2020 (opens in a new tab)), sodas and concentrated juices (ACR (opens in a new tab)).
A Mediterranean or DASH-style diet may help prevent attacks and is good for the heart (Arthritis Foundation (opens in a new tab)). Talk with your doctor before changing your diet or medicines (NIAMS (opens in a new tab)).
Member stories
Living with Gout? Share your experience
Real experiences help others choose. Tell us what you tried — conventional medicine, chiropractic, acupuncture, herbs, massage or coaching — what it cost and what changed.
Sources
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) — Gout (opens in a new tab)
- NIAMS — Gout: diagnosis, treatment and steps to take (opens in a new tab)
- American College of Rheumatology (ACR) — Gout (patient fact sheet) (opens in a new tab)
- ACR — Calcium pyrophosphate deposition (CPPD) (patient fact sheet) (opens in a new tab)
- FitzGerald et al. — 2020 American College of Rheumatology guideline for the management of gout, Arthritis Care & Research, 2020 (PubMed; full text read from the ACR guideline page) (opens in a new tab)
- CDC — Gout (opens in a new tab)
- Arthritis Foundation — Gout (opens in a new tab)
- Arthritis Foundation — Infectious arthritis (opens in a new tab)
- MedlinePlus — Gout (opens in a new tab)
- MedlinePlus — Uric acid test (opens in a new tab)
- MedlinePlus — Kidney stones (opens in a new tab)
- MedlinePlus — Allopurinol (drug information) (opens in a new tab)
- MedlinePlus — Febuxostat (drug information) (opens in a new tab)
- DailyMed — Uloric (febuxostat) FDA-approved prescribing information, with boxed warning (opens in a new tab)
- NHS — Gout (opens in a new tab)
- NHS — Kidney stones (opens in a new tab)
- NHS — Cellulitis (opens in a new tab)
- NIDDK — Symptoms and causes of kidney stones (opens in a new tab)
- NIDDK — Eating, diet and nutrition for kidney stones (opens in a new tab)
- Arthritis UK (formerly Versus Arthritis) — Gout (opens in a new tab)
- Chen-Xu et al. — Contemporary prevalence of gout and hyperuricemia in the United States and decadal trends (NHANES 2007–2016), Arthritis & Rheumatology, 2019 (PubMed) (opens in a new tab)
- Zhang et al. — Changes of serum uric acid level during acute gout flare and related factors, Frontiers in Endocrinology, 2023 (PubMed) (opens in a new tab)
- White et al. — Cardiovascular safety of febuxostat or allopurinol in patients with gout (CARES), New England Journal of Medicine, 2018 (PubMed) (opens in a new tab)
- Zhang et al. — Cherry consumption and decreased risk of recurrent gout attacks, Arthritis & Rheumatism, 2012 (PubMed) (opens in a new tab)
- Juraschek et al. — Effect of oral vitamin C supplementation on serum uric acid: a meta-analysis of randomized controlled trials, Arthritis Care & Research, 2011 (PubMed) (opens in a new tab)
- Choi et al. — Vitamin C intake and the risk of gout in men: a prospective study, Archives of Internal Medicine, 2009 (PubMed) (opens in a new tab)
- Stamp et al. — Clinically insignificant effect of supplemental vitamin C on serum urate in patients with gout: a pilot randomized controlled trial, Arthritis & Rheumatism, 2013 (PubMed) (opens in a new tab)
- Andrés et al. — Dietary supplements for chronic gout, Cochrane review, 2021 (PubMed) (opens in a new tab)
- Pardali et al. — Effect of diet and dietary supplements on gout-related outcomes: a systematic review of randomised controlled trials, Mediterranean Journal of Rheumatology, 2025 (PubMed) (opens in a new tab)
- Choi et al. — Coffee consumption and risk of incident gout in men: a prospective study, Arthritis & Rheumatism, 2007 (PubMed) (opens in a new tab)
- Choi and Curhan — Coffee consumption and risk of incident gout in women: the Nurses’ Health Study, American Journal of Clinical Nutrition, 2010 (PubMed) (opens in a new tab)
- Li et al. — Anti-gouty arthritis and anti-hyperuricemia properties of celery seed extracts in rodent models, Molecular Medicine Reports, 2019 (PubMed) (opens in a new tab)
- Escobedo-Gutiérrez et al. — Effect of celery seed administration on the components of metabolic syndrome, insulin sensitivity, and insulin secretion: a clinical trial, Pharmaceuticals, 2026 (PubMed) (opens in a new tab)
- Lee et al. — Acupuncture for gouty arthritis: a concise report of a systematic and meta-analysis approach, Rheumatology, 2013 (PubMed) (opens in a new tab)
- Lu et al. — Update on the clinical effect of acupuncture therapy in patients with gouty arthritis: systematic review and meta-analysis, Evidence-Based Complementary and Alternative Medicine, 2016 (PubMed) (opens in a new tab)
- Ni et al. — Electroacupuncture for acute gouty arthritis: a systematic review and meta-analysis of randomized controlled trials, Frontiers in Immunology, 2024 (PMC) (opens in a new tab)
- Fan et al. — Comparison of efficacy of acupuncture-related therapies in treating acute gouty arthritis: a network meta-analysis of randomized controlled trials, Heliyon, 2024 (PubMed) (opens in a new tab)
- McConville and Cox — Spinal gout diagnosis in chiropractic practice: narrative review, Journal of the Canadian Chiropractic Association, 2023 (PubMed) (opens in a new tab)
- NCCIH — Using dietary supplements wisely (opens in a new tab)
- NCCIH — Acupuncture: effectiveness and safety (opens in a new tab)
- NCCIH — Massage therapy: what you need to know (opens in a new tab)
- NCCIH — Spinal manipulation: what you need to know (opens in a new tab)
- The Pricer — Acupuncture cost (opens in a new tab)
- CostHelper — How much does a massage cost? (opens in a new tab)
This page is for education only and is not medical advice. Costs are typical U.S. ranges and estimates; yours will depend on your provider, location and insurance. Talk with your doctor before starting, stopping or combining any treatment. In an emergency, call 911. See our disclaimer.
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