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Genital Herpes
A very common, lifelong skin infection caused by the herpes simplex virus. Most people have no symptoms or mild ones. There is no cure, but antiviral medicine controls outbreaks and lowers the chance of passing it on — and a newborn who seems unwell needs care right away.
What is genital herpes?
Genital herpes is a sexually transmitted infection (STI) caused by the herpes simplex virus (HSV) (MedlinePlus (opens in a new tab)). It is lifelong, but it can be treated and managed, and outbreaks often become less frequent over time (CDC (opens in a new tab)). Having it says nothing about your worth as a person — and, as the numbers below show, it is very common.
- HSV-2 spreads through sexual contact and is the main cause of genital herpes and of most repeat outbreaks (WHO (opens in a new tab), CDC STI Treatment Guidelines (opens in a new tab)).
- HSV-1 usually causes cold sores, often caught in childhood through non-sexual contact with saliva. It can reach the genitals through oral sex, and a growing share of genital herpes is caused by HSV-1 (CDC (opens in a new tab), CDC STI Treatment Guidelines (opens in a new tab)). Genital HSV-1 comes back less often than genital HSV-2 (CDC STI Treatment Guidelines (opens in a new tab)).
For sores on or around the mouth, see our Cold Sores guide.
How common is it?
A U.S. national survey found antibodies to HSV-2 in 11.9% of people aged 14 to 49 in 2015–2016 — more often in women than men (15.9% vs 8.2%, adjusted for age) — down from 18.0% in 1999–2000 (age-adjusted) (CDC National Center for Health Statistics (opens in a new tab)). CDC estimates there were 572,000 new genital herpes infections among people aged 14 to 49 in the U.S. in 2018 (CDC (opens in a new tab)). Worldwide, about 520 million people aged 15 to 49 (13%) have HSV-2 (WHO (opens in a new tab)).
How does it spread?
Through vaginal, anal or oral sex — contact with a herpes sore, genital skin or fluids, or, for HSV-1, the saliva or mouth area of a partner with oral herpes (CDC (opens in a new tab)). Shared sex toys can also pass it on (NHS (opens in a new tab)).
- Without symptoms. The virus can spread when no sores are present (MedlinePlus (opens in a new tab)). Most people with HSV-2 have never been diagnosed, and most genital herpes is passed on by people who don’t know they have it or have no symptoms at the time. This silent shedding is most frequent in the first year after getting HSV-2 (CDC STI Treatment Guidelines (opens in a new tab)).
- Most contagious from the first tingle of an outbreak until sores have fully healed (NHS (opens in a new tab), WHO (opens in a new tab)).
- Not from objects such as toilet seats, bedding, pools, silverware or towels (CDC (opens in a new tab)).
Symptoms and outbreaks
Most people have no symptoms or mild ones mistaken for a pimple or ingrown hair, so most don’t know they have herpes (CDC (opens in a new tab)). When symptoms appear, they may include tingling, itching or burning before sores form (WHO (opens in a new tab)); blisters on or around the genitals, rectum or mouth that break into painful sores and may take a week or more to heal (CDC (opens in a new tab)), sometimes on the buttocks or thighs (MedlinePlus (opens in a new tab)); pain when peeing or unusual discharge (NHS (opens in a new tab)); and, with a first outbreak, fever, body aches or swollen glands (CDC (opens in a new tab)).
Symptoms may not appear for weeks or even years after infection. The virus stays in a nearby nerve and can flare in the same area (NHS (opens in a new tab)). Repeat outbreaks are common in the first year, but they tend to become milder and less frequent (MedlinePlus (opens in a new tab)), and some people never have another (NHS (opens in a new tab)). See a provider about any unusual sore, discharge or burning when you pee (CDC (opens in a new tab)); these can have other causes too. For women, see also our Female Problems guide.
Testing
- With a sore: a swab from a blister or sore that hasn’t crusted over is the best test (CDC (opens in a new tab)). A PCR test is faster and more accurate than a culture (MedlinePlus (opens in a new tab)), and it shows whether the virus is HSV-1 or HSV-2, which helps predict how often it may return (CDC STI Treatment Guidelines (opens in a new tab)). Go while sores are fresh.
- Without sores: a blood test looks for antibodies (CDC (opens in a new tab)), but it has real limits. It can miss a recent infection — antibodies take up to three months to form (MedlinePlus (opens in a new tab)) — and false positives are far more likely than with chlamydia or gonorrhea tests, especially in people at low risk (CDC (opens in a new tab)). A low positive on the most common HSV-2 test should be confirmed with a second method (CDC STI Treatment Guidelines (opens in a new tab)). No blood test can tell when you were infected or by whom (CDC (opens in a new tab)).
- No routine screening. CDC recommends herpes testing for people with genital symptoms and does not recommend it for people without symptoms in most situations. A blood test may help if a current or past partner has genital herpes (CDC (opens in a new tab)). A “test for everything” may not include herpes, so ask (CDC (opens in a new tab)).
Find confidential, free or low-cost testing with CDC’s GetTested (opens in a new tab).
Lowering the chance of passing it on
- No sex during outbreaks or warning tingles (NHS (opens in a new tab)).
- Condoms every time. They lower but don’t remove the risk (MedlinePlus (opens in a new tab)), because sores can occur where a condom doesn’t cover and skin can shed virus without a visible sore (CDC (opens in a new tab)). Dental dams can be used for oral sex (CDC (opens in a new tab)).
- Daily antiviral medicine taken by the partner who has herpes (CDC (opens in a new tab)) — see Conventional medicine below.
- Talk with partners — see Talking with partners.
Herpes and HIV
Herpes sores give HIV a way into the body, and even without sores herpes increases the immune cells in the genital lining that HIV targets (CDC (opens in a new tab)). HSV-2 raises the risk of getting HIV about two- to three-fold (CDC STI Treatment Guidelines (opens in a new tab), WHO (opens in a new tab)), and people with both are more likely to pass HIV on (WHO (opens in a new tab)). Everyone with genital herpes should be tested for HIV (CDC STI Treatment Guidelines (opens in a new tab)). Herpes testing or treatment doesn’t lower HIV risk (CDC (opens in a new tab)). See our HIV & AIDS guide for testing and PrEP.
Eyes, and shingles
Touching sores can carry the virus to the eyes, so don’t touch them, and wash your hands right away if you do (CDC (opens in a new tab)). Herpes eye infection is rare and is treated with antiviral medicine prescribed by a doctor (WHO (opens in a new tab), CDC (opens in a new tab)); see our Eyes and Cold Sores guides. Shingles (herpes zoster) is a different virus: the chickenpox virus waking up again (CDC (opens in a new tab)). MBHA plans a separate Shingles guide.
Get medical care right away if:
- A newborn seems unwell — fever, feeding poorly, irritable, or a rash or sores on the skin, eyes or mouth. Call 911 if the baby is floppy, sluggish, hard to wake, breathing with difficulty, has a seizure, or has blue skin or lips. Babies can become very ill quickly, often with no blisters at all (NHS (opens in a new tab), MedlinePlus (opens in a new tab)). Neonatal herpes can be deadly (CDC (opens in a new tab)) and needs prompt antiviral treatment (CDC STI Treatment Guidelines (opens in a new tab)).
- A sore near your eye, or eye pain, intense redness or light sensitivity — see a doctor the same day (CDC (opens in a new tab), CDC (opens in a new tab)).
- Severe headache, stiff neck, fever, light sensitivity, behavior changes, unusual drowsiness or a seizure with an outbreak. Rarely, herpes causes meningitis or encephalitis, which need hospital care (CDC STI Treatment Guidelines (opens in a new tab), WHO (opens in a new tab), MedlinePlus (opens in a new tab), MedlinePlus (opens in a new tab)).
- You are pregnant with a first outbreak, or an outbreak or symptoms near delivery — tell your prenatal care provider right away (CDC (opens in a new tab), WHO (opens in a new tab)). The baby’s risk is highest when herpes is caught near delivery (CDC STI Treatment Guidelines (opens in a new tab)).
- You have a weakened immune system and an outbreak; herpes can be severe (CDC (opens in a new tab), CDC STI Treatment Guidelines (opens in a new tab)).
Side by side
Six approaches compared
For every condition we look at the same six approaches: what each involves, what it typically costs, and what a patient can realistically expect.
| Approach | What it involves | Estimated cost | What to expect |
|---|---|---|---|
| Conventional medicine (AMA) | Swab testing of sores; prescription antivirals (acyclovir, valacyclovir, famciclovir) taken for each outbreak or every day as suppressive therapy; late-pregnancy antivirals and a C-section if sores are present at delivery. | Cost estimate being researched (antivirals, visits and tests). Free or low-cost STI testing is available at many clinics. | Antivirals shorten and ease outbreaks, and daily therapy cuts recurrences by 70–80% in people with frequent outbreaks and lowers the chance of passing HSV-2 to a partner. There is no cure. |
| Chiropractic | No role in treating herpes, which is a viral infection. | Not applicable. | Spinal care does not act on the herpes virus. Rely on medical care for outbreaks and prevention. |
| Acupuncture | No established role. We found little research on acupuncture for genital herpes. | Cost estimate being researched. | No good evidence it prevents or shortens outbreaks. Never place needles on or near sores. |
| Herbal medicine | Propolis ointment, topical zinc, lemon balm and lysine supplements have been tried. None cures herpes or replaces antiviral medicine. | Cost estimate being researched. | Small, older studies of propolis and topical zinc look promising but are weak; lemon balm is studied mainly in cold sores; evidence for lysine is mixed and weak. Check interactions and allergies first. |
| Massage therapy | No role in treating herpes. If you have massage for other reasons, keep well away from any sores. | Cost estimate being researched. | Does not affect the virus. Avoid any contact with sores; reschedule during an outbreak in the area to be massaged. |
| MBHA Wellness Coach | Learning your triggers, sleep and stress care, condoms and dental dams, preparing to talk with partners, and support for stigma, anxiety and low mood. | Cost estimate being researched. | Helps you feel more in control, may mean fewer outbreaks from avoidable triggers, and supports safer, more confident relationships — alongside, never instead of, medical care. |
Approach 1 of 6
Conventional medicine (AMA)
There is no cure, but medicine can prevent or shorten outbreaks and make it less likely you pass herpes on (CDC (opens in a new tab)). We don’t list doses — your clinician will choose the medicine and schedule for you.
1. The antiviral medicines
Three antivirals are approved for genital herpes: acyclovir, valacyclovir and famciclovir. Antiviral creams offer little benefit for genital herpes and are discouraged. The tablets control symptoms but don’t clear the virus or change how often outbreaks happen after you stop them; allergic and other reactions are rare (CDC STI Treatment Guidelines (opens in a new tab)). They don’t cure herpes (MedlinePlus (opens in a new tab)). Everyone with a first episode should get antiviral treatment, because a new infection can cause a long, painful illness (CDC STI Treatment Guidelines (opens in a new tab)).
2. Episodic or suppressive therapy?
- Episodic: a short course at the first sign of each outbreak. It works best started during the warning tingle or within a day of sores appearing, so providers often give a prescription to keep on hand (CDC STI Treatment Guidelines (opens in a new tab)). It may shorten an outbreak by a day or two (NHS (opens in a new tab)).
- Suppressive: an antiviral every day. It cuts recurrences by 70–80% in people with frequent outbreaks; many report none at all. Long-term safety is well documented, and quality of life improves for many people. Because outbreaks lessen over time, review it with your provider each year (CDC STI Treatment Guidelines (opens in a new tab)). For genital HSV-1, daily therapy is usually kept for frequent outbreaks, and it can be considered for anyone in real distress about the diagnosis (CDC STI Treatment Guidelines (opens in a new tab)).
3. Protecting partners
Where one partner has a history of genital HSV-2, daily valacyclovir lowered transmission, and CDC encourages such couples to consider suppressive therapy alongside condoms and avoiding sex during outbreaks. Limits: it hasn’t been studied in people whose HSV-2 was found only by a blood test, or for genital HSV-1, and in people with HIV it did not reduce transmission of HSV-2 or HIV. A partner without herpes should not take antivirals to try to prevent it (CDC STI Treatment Guidelines (opens in a new tab)). Spread is still possible on treatment (MedlinePlus (opens in a new tab)).
4. In pregnancy
Acyclovir is believed safe in pregnancy and breastfeeding. For recurrent genital herpes, daily antivirals from 36 weeks reduce outbreaks at term and the need for a cesarean, though they may not prevent every newborn infection. People with herpes sores at the start of labor should have a cesarean, which lowers but doesn’t remove the baby’s risk (CDC STI Treatment Guidelines (opens in a new tab)). See Herpes and pregnancy.
5. Easing an outbreak
Keep the area clean with plain or salt water, use a wrapped ice pack (never ice straight on skin), and avoid tight clothing (NHS (opens in a new tab)). A warm bath without soap, loose clothes and over-the-counter pain relievers can help (WHO (opens in a new tab)). Petroleum jelly, or pouring water over the area while you pee, can ease painful peeing (NHS (opens in a new tab)). Wash your hands after touching sores (CDC (opens in a new tab)).
Who to see
Your primary care provider or a sexual health clinic (NHS (opens in a new tab)). Sores that keep returning despite treatment may be drug-resistant and are managed with an infectious disease specialist (CDC STI Treatment Guidelines (opens in a new tab)).
What it costs
Antivirals, visits and tests: cost estimate being researched. For free or low-cost testing, search CDC’s GetTested (opens in a new tab).
How well it works — what to expect
Expect shorter, milder outbreaks with treatment, fewer outbreaks with daily therapy for many people, and a lower risk to partners. Antivirals control herpes; they don’t cure it. It is manageable with medicine (CDC (opens in a new tab)).
Approach 2 of 6
Chiropractic
Chiropractic care has no role in treating genital herpes, which is a viral infection. Spinal care does not act on the virus, and we found little research on chiropractic for herpes. For outbreaks and protecting partners, see Conventional medicine.
Approach 3 of 6
Acupuncture
We found little research on acupuncture for genital herpes, and nothing showing it prevents or shortens outbreaks. It should never replace antiviral medicine.
- Never have needles or cupping on or near sores. Doctors have reported a herpes skin infection that appeared after acupuncture and cupping on the forearm (case report, Annals of Dermatology (opens in a new tab)).
- Choose a licensed practitioner using sterile, single-use needles; complications have come from non-sterile needles and poor technique (NCCIH (opens in a new tab)).
What it costs
Cost estimate being researched.
Approach 4 of 6
Herbal medicine
Read this first. No herb or supplement cures herpes or replaces antiviral medicine; online herpes “cures” made from natural products are unproven (narrative review, Viruses (opens in a new tab)). If you are pregnant, have a weakened immune system or a first outbreak, see a clinician rather than self-treating. We don’t list strengths or doses.
Propolis
Propolis is a resin-like material made by bees (narrative review, Viruses (opens in a new tab)). In a 2000 study of 90 people with recurrent genital HSV-2, more people using propolis ointment had healed by day 10 (24 of 30) than with acyclovir ointment (14 of 30) or a dummy ointment (12 of 30); the study was small and only single-blind (trial, Phytomedicine (opens in a new tab)). A 2026 analysis of 7 studies of lip and genital herpes found propolis and/or honey healed faster than acyclovir cream (meta-analysis, International Journal of STD and AIDS (opens in a new tab)), but another review called the evidence inconclusive because of low quality and small samples (systematic review, Evidence-Based Complementary and Alternative Medicine (opens in a new tab)). The head-to-head comparisons were with acyclovir cream or ointment, which CDC discourages for genital herpes in favor of tablets (CDC STI Treatment Guidelines (opens in a new tab)). Propolis is a known contact allergen; people allergic to bee stings, honey, ragweed or chrysanthemums should not use it (Memorial Sloan Kettering (opens in a new tab)).
Topical zinc
In one small 2013 study in India, fewer people who applied zinc sulfate solutions had a recurrence over 6 months than in a 10-person water group, with no serious side effects. Herpes was diagnosed with a smear test (study, Indian Journal of Sexually Transmitted Diseases and AIDS (opens in a new tab)) that CDC says should not be relied on (CDC STI Treatment Guidelines (opens in a new tab)). That is too little to go on.
Lemon balm (Melissa)
Lemon balm extract blocked HSV-2 in cell studies, and its human trials have been in cold sores (narrative review, Viruses (opens in a new tab)). We found little research on it for genital herpes, though it is a popular self-help choice among UK support group members (survey, International Journal of STD and AIDS (opens in a new tab)). See our Cold Sores guide for the trials.
Lysine
The evidence for this amino acid supplement is mixed and weak. A 1985 trial was titled “Failure of lysine in frequently recurrent herpes simplex infection” (trial, Archives of Dermatology (opens in a new tab)). A 2017 review found it ineffective at lower intakes, with only better self-reported experience at higher ones; it called for longer controlled studies and warned people with heart or gallbladder disease of theoretical risks (review, Integrative Medicine (opens in a new tab)). A more hopeful 2023 review has an author who works with a biotech company (narrative review, Viruses (opens in a new tab)).
Interactions
Tell your doctor and pharmacist about every herb or supplement you use, because some interact with medicines (NCCIH (opens in a new tab)). Use them alongside your antiviral plan, never instead of it.
What it costs
Cost estimate being researched.
Approach 5 of 6
Massage therapy
Massage has no role in treating herpes; it doesn’t affect the virus. If you enjoy massage for relaxation, the risk of harm from massage generally appears low (NCCIH (opens in a new tab)).
MBHA caution: avoid any contact with sores. During an outbreak in or near an area to be massaged, reschedule; therapists should not work over blisters or broken skin. Herpes isn’t spread by towels or bedding, but it does spread through contact with a sore (CDC (opens in a new tab)).
What it costs
Cost estimate being researched.
Approach 6 of 6
MBHA Wellness Coach
An MBHA Wellness Coach can help you live comfortably and confidently with herpes, alongside — never instead of — your doctor or clinic.
Learn your triggers
Things that can set off outbreaks include friction from sex or tight clothing (lubricant may help), sun or sunbeds on the area, smoking, alcohol, being unwell, stress, your period, and surgery in the area (NHS (opens in a new tab)), as well as fever and injury (WHO (opens in a new tab)). Some can’t be avoided (NHS (opens in a new tab)). A simple diary of what came before each outbreak helps you and your provider choose between episodic and daily treatment.
Sleep and stress
Most adults need 7 or more hours of sleep; enough sleep helps you get sick less often and ease stress. Regular sleep times, a cool, quiet room and no screens before bed help (CDC (opens in a new tab)). A review of prospective studies found suggestive evidence that chronic stress or depression comes before more frequent outbreaks, and recommended combining medicine with psychological support (review, International Journal of STD and AIDS (opens in a new tab)). Your coach can help you build a stress routine you’ll keep.
Condoms and dental dams
Use a new condom for the whole of every act of vaginal, anal or oral sex (CDC (opens in a new tab)), and a new latex or polyurethane dental dam each time for oral sex on the vagina or anus, with water- or silicone-based lubricant, never oil-based products (CDC (opens in a new tab)). Neither removes the risk completely (MedlinePlus (opens in a new tab)).
Stigma and mental health
Genital herpes can be stigmatizing and affect relationships (WHO (opens in a new tab)). A review of 30 studies found people may feel depression, anxiety, isolation, stigma and lower self-esteem, and that counseling, psychosocial support and treatment helped some of these, though which approach works best is still unclear (systematic review, JBI Evidence Synthesis (opens in a new tab)). One review describes a cycle in which distress and frequent outbreaks feed each other (review, Journal of Health Psychology (opens in a new tab)). If worry or low mood weighs on you, tell your provider, and see our Anxiety and Depression guides.
Support
CDC points people with herpes and their partners to the American Sexual Health Association (CDC STI Treatment Guidelines (opens in a new tab)): ashasexualhealth.org (opens in a new tab). Support groups can ease the stigma many people feel (survey, International Journal of STD and AIDS (opens in a new tab)).
Another approach
Herpes and pregnancy
People who had genital herpes before pregnancy can usually expect a healthy baby (NHS (opens in a new tab)). What matters most is that your prenatal care team knows, and avoiding a new infection late in pregnancy. MBHA plans a separate Pregnancy guide.
- Tell your provider about any past herpes diagnosis, symptoms or possible exposure (CDC (opens in a new tab)).
- Timing matters. The risk to the baby is high (30–50%) when herpes is first caught near delivery, and low (under 1%) for people who had it before pregnancy or caught it in the first half (CDC STI Treatment Guidelines (opens in a new tab)).
- Avoid a new infection. If you don’t have genital herpes, CDC advises no vaginal sex in the third trimester with a partner who has or may have it, and no receptive oral sex then with a partner who has or may have cold sores (CDC STI Treatment Guidelines (opens in a new tab)).
- Near delivery you may be offered antiviral medicine; your provider should check for sores, and a C-section is likely if you have signs or symptoms then (CDC (opens in a new tab)).
- Routine blood screening in pregnancy isn’t recommended (CDC STI Treatment Guidelines (opens in a new tab)).
Neonatal herpes
Herpes passes to a baby most often during delivery and can be deadly in a newborn (CDC (opens in a new tab)). Many mothers of affected babies never knew they had herpes (CDC STI Treatment Guidelines (opens in a new tab)). After birth, a baby can catch it from a cold sore kiss or a herpes blister on a breast or finger; everyone should wash their hands before handling the baby, and anyone with a sore should not kiss the baby (NHS (opens in a new tab)). Watch for the warning signs at the top of this page.
Another approach
Talking with partners
CDC encourages telling current partners, and telling new partners before a sexual relationship begins (CDC STI Treatment Guidelines (opens in a new tab)). Disclosure is often stressful (systematic review, JBI Evidence Synthesis (opens in a new tab)), but it often goes better than people fear: in a UK support group survey, 83% of members who told a partner were not rejected (survey, International Journal of STD and AIDS (opens in a new tab)).
- Pick a calm moment and have the facts ready: herpes is common, often silent and manageable with medicine (CDC National Center for Health Statistics (opens in a new tab), CDC (opens in a new tab)).
- Share your plan: no sex during outbreaks, condoms, and whether daily medicine makes sense (CDC STI Treatment Guidelines (opens in a new tab)).
- Your partner may already have it. A partner without symptoms can be offered a type-specific blood test (CDC STI Treatment Guidelines (opens in a new tab)).
- Blame doesn’t fit the facts. A blood test can’t show when you were infected or by whom (CDC (opens in a new tab)), and symptoms can take years to appear (NHS (opens in a new tab)).
An MBHA Wellness Coach can help you rehearse the conversation.
Member stories
Living with Genital Herpes? Share your experience
Real experiences help others choose. Tell us what you tried — conventional medicine, chiropractic, acupuncture, herbs, massage or coaching — what it cost and what changed.
Sources
- CDC — About genital herpes (opens in a new tab)
- CDC — Screening for genital herpes (testing FAQ) (opens in a new tab)
- CDC — Sexually Transmitted Infections Treatment Guidelines, 2021: Genital herpes (opens in a new tab)
- CDC National Center for Health Statistics — Prevalence of herpes simplex virus type 1 and type 2 in persons aged 14–49: United States, 2015–2016 (Data Brief No. 304) (opens in a new tab)
- CDC — Condom use: an overview (opens in a new tab)
- CDC — How to use a dental dam (opens in a new tab)
- CDC — How to treat pink eye (opens in a new tab)
- CDC — About shingles (herpes zoster) (opens in a new tab)
- CDC — About sleep (opens in a new tab)
- CDC — GetTested: find HIV, STI and hepatitis testing near you (opens in a new tab)
- MedlinePlus — Genital herpes (health topic) (opens in a new tab)
- MedlinePlus — Herpes (HSV) test (opens in a new tab)
- MedlinePlus — Acyclovir (drug information) (opens in a new tab)
- MedlinePlus — Valacyclovir (drug information) (opens in a new tab)
- MedlinePlus — Meningitis (health topic) (opens in a new tab)
- MedlinePlus — Encephalitis (health topic) (opens in a new tab)
- NHS — Genital herpes (opens in a new tab)
- NHS — Neonatal herpes (herpes in a baby) (opens in a new tab)
- World Health Organization — Herpes simplex virus (fact sheet) (opens in a new tab)
- Memorial Sloan Kettering Cancer Center — Propolis (About Herbs) (opens in a new tab)
- NCCIH — Herb-drug interactions: what the science says (opens in a new tab)
- NCCIH — Acupuncture: effectiveness and safety (opens in a new tab)
- NCCIH — Massage therapy: what you need to know (opens in a new tab)
- Vynograd et al. — A comparative multi-centre study of the efficacy of propolis, acyclovir and placebo in the treatment of genital herpes (HSV), Phytomedicine, 2000 (PubMed abstract) (opens in a new tab)
- Sung et al. — External use of propolis for oral, skin, and genital diseases: a systematic review and meta-analysis, Evidence-Based Complementary and Alternative Medicine, 2017 (PubMed abstract) (opens in a new tab)
- Niode et al. — Superiority of propolis and honey over topical acyclovir for herpes simplex: a meta-analysis, International Journal of STD and AIDS, 2026 (PubMed abstract) (opens in a new tab)
- Mahajan et al. — Herpes genitalis: topical zinc sulfate, an alternative therapeutic modality, Indian Journal of Sexually Transmitted Diseases and AIDS, 2013 (PubMed abstract) (opens in a new tab)
- Mailoo & Rampes — Lysine for herpes simplex prophylaxis: a review of the evidence, Integrative Medicine, 2017 (PubMed abstract) (opens in a new tab)
- Simon et al. — Failure of lysine in frequently recurrent herpes simplex infection, Archives of Dermatology, 1985 (PubMed citation) (opens in a new tab)
- Chang et al. — A narrative review of alternative symptomatic treatments for herpes simplex virus, Viruses, 2023 (PubMed Central) (opens in a new tab)
- Goldmeier et al. — Does chronic stress lead to increased rates of recurrences of genital herpes? A review of the psychoneuroimmunological evidence, International Journal of STD and AIDS, 2008 (PubMed abstract) (opens in a new tab)
- Bennett et al. — Impact of primary and recurrent genital herpes on the quality of life of young people and adults: a mixed methods systematic review, JBI Evidence Synthesis, 2022 (PubMed abstract) (opens in a new tab)
- Merin & Pachankis — The psychological impact of genital herpes stigma, Journal of Health Psychology, 2011 (PubMed abstract) (opens in a new tab)
- Nicholson & O’Farrell — Genital herpes: diagnosis, treatments, attitudes and response to disclosure amongst members of the UK Herpes Viruses Association, International Journal of STD and AIDS, 2021 (PubMed abstract) (opens in a new tab)
- Jung et al. — A herpes simplex virus infection secondary to acupuncture and cupping, Annals of Dermatology, 2011 (PubMed abstract) (opens in a new tab)
This page is for education only and is not medical advice. Costs are typical U.S. ranges and estimates; yours will depend on your provider, location and insurance. Talk with your doctor before starting, stopping or combining any treatment. In an emergency, call 911. See our disclaimer.
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