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Leukemia

Cancers of the blood cells that start in the bone marrow. The four main types — ALL, AML, CLL and CML — behave and are treated very differently. Leukemia is most common in older adults, yet it is also the most common cancer in children, and most children with ALL now survive.

Being treated for leukemia? Call your oncology team right away — even in the middle of the night — or go to the emergency room for:

  • A fever of 100.4°F (38°C) or higher. During chemotherapy this is a medical emergency: fever may be the only sign of an infection, and infection can be life-threatening (CDC (opens in a new tab)). Chemotherapy lowers the white blood cells that fight infection (neutropenia) (CDC (opens in a new tab)), often most between 7 and 12 days after a treatment (CDC (opens in a new tab)). At the emergency room, say you are a cancer patient getting chemotherapy, so you are seen quickly (CDC (opens in a new tab)). Ask your team before taking anything to lower a fever, because it can hide a serious problem (National Cancer Institute (opens in a new tab)).
  • Other signs of infection: chills and sweats, a new or changed cough, shortness of breath, a sore throat or mouth sore, a stiff neck, pain when urinating, or redness or swelling anywhere, including around ports (CDC (opens in a new tab)).
  • Unusual bleeding: bleeding that doesn’t stop after a few minutes; bleeding from the mouth or nose or when you vomit; red or pink urine; black or bloody stools; or a much heavier period (NCI (opens in a new tab)).
  • Confusion, severe headache, unusual sleepiness, slurred speech or weakness on one side. With low platelets, NCI says to call about bad headaches, vision changes, or feeling confused or very sleepy (NCI (opens in a new tab)). Very high leukemia counts can clog small blood vessels (leukostasis), causing stroke-like symptoms; ACS says this is rare but a medical emergency (American Cancer Society (opens in a new tab)). Confusion and impaired speech are also signs of a nerve side effect of CAR T-cell therapy (NCI (opens in a new tab)).
  • Trouble breathing. Leukostasis in the lungs can cause shortness of breath (ACS (opens in a new tab)). The NHS says to call emergency services for a swollen, red face, neck, arms or hands, or swollen veins in the neck or chest, that come on suddenly (NHS (opens in a new tab)). If you are struggling to breathe, call 911.

Keep your care team’s daytime and after-hours numbers with you (CDC (opens in a new tab)). Never wait for an acupuncture, massage or chiropractic appointment for any of these.

Complementary therapies are used alongside, never instead of, leukemia treatment. No complementary approach has been shown to cure cancer or make it go into remission, and some may interfere with cancer treatment (NCCIH, U.S. National Institutes of Health (opens in a new tab)). Tell your oncology team about every supplement, even vitamins (NCI (opens in a new tab)). See also our Cancer guide.

What is leukemia?

Leukemia is a term for cancers of the blood cells. It starts in blood-forming tissue such as the bone marrow, which makes white blood cells (to fight infection), red blood cells (to carry oxygen) and platelets (to help blood clot). In leukemia the marrow makes large numbers of abnormal cells, most often white blood cells, which crowd out healthy blood cells, leading to infection, anemia and easy bleeding (MedlinePlus (opens in a new tab), National Cancer Institute (opens in a new tab)). Its cause is unknown; it happens when the genetic material (DNA) in bone marrow cells changes (MedlinePlus (opens in a new tab)).

Leukemia is named for the kind of blood cell involved — lymphocytic (a type of white blood cell) or myeloid — and for how fast it grows. Acute leukemia grows quickly and usually gets worse fast without treatment; chronic leukemia grows slowly (MedlinePlus (opens in a new tab)).

The four main types — and who gets each

About 67,790 new U.S. cases of leukemia are expected in 2026, and about 1.6% of people are diagnosed with it in their lifetime (NCI SEER (opens in a new tab)). It occurs most often in adults older than 55, but it is also the most common cancer in children younger than 15 (NCI (opens in a new tab)).

Leukemia in children

ALL makes up about 25% of all childhood cancers in the U.S. and occurs most often between ages 1 and 4 (NCI (opens in a new tab)). About 3 in 4 childhood leukemias are ALL and most of the rest are AML; chronic leukemias are rare in children (American Cancer Society (opens in a new tab)). The exact cause is often unknown; inherited conditions such as Down syndrome raise the risk, and genetic counseling can help families learn whether it might be inherited (NCI (opens in a new tab)).

Symptoms

Early symptoms can look like the flu or other common illnesses (NCI (opens in a new tab)). Check with a doctor if any of these don’t go away:

Acute leukemia symptoms often develop over a few weeks (NHS (opens in a new tab)). CLL often causes no symptoms at first and is found on a routine blood test (NCI (opens in a new tab)).

Diagnosis

  • Blood tests. A complete blood count (CBC) counts red cells, white cells and platelets; a blood smear looks for immature “blast” cells (NCI (opens in a new tab)).
  • Bone marrow aspiration and biopsy. After the skin is numbed, a hollow needle removes marrow, blood and a small piece of bone from the hipbone or breastbone, to look for leukemia cells (NCI (opens in a new tab)).
  • Genetic and molecular tests. Cytogenetic tests and FISH look for changed chromosomes, such as the Philadelphia chromosome; molecular tests look for gene changes that help plan treatment and predict outlook; flow cytometry and immunophenotyping identify the exact type (NCI (opens in a new tab)).
  • Spread. A lumbar puncture (spinal tap) checks for leukemia cells around the brain and spinal cord, and imaging may also be used (MedlinePlus (opens in a new tab)).

Outlook by type

For people diagnosed in 2016–2022, 5-year relative survival was 68.6% for leukemia overall (NCI SEER Program (opens in a new tab)), but the types differ widely:

These numbers come from large groups and can’t predict one person’s outcome (NCI SEER (opens in a new tab)), and children diagnosed today might do better, because treatment keeps improving (ACS (opens in a new tab)).

Side by side

Six approaches compared

For every condition we look at the same six approaches: what each involves, what it typically costs, and what a patient can realistically expect.

Leukemia: six approaches compared
ApproachWhat it involves Estimated costWhat to expect
Conventional medicine (AMA) Treatment by type: chemotherapy for acute leukemias; TKIs such as imatinib for CML; watch-and-wait, then BTK inhibitors or venetoclax for CLL; blinatumomab and CAR T-cell therapy for some ALL; stem cell transplant; clinical trials. Cost estimate being researched. Insurance, Medicare, Medicaid and nonprofit programs can help. The treatment that puts leukemia into remission or controls it. 5-year relative survival ranges from 33.4% (AML) to 90.2% (CLL); about 90% of children with ALL survive 5 years.
Chiropractic No role in treating leukemia. Possibly gentle care for ordinary back or neck pain — only with your oncologist’s OK. About $55–$100 a self-pay follow-up visit; first visits about $90–$200. No evidence it affects leukemia. Skip it while platelets are low; bone or joint pain can be a leukemia symptom and needs your cancer team first.
Acupuncture Used alongside treatment for chemotherapy nausea and vomiting and for fatigue. About $90–$185 a follow-up visit cash-pay; community clinics about $50–$90. Strongest evidence is for treatment-related nausea; fatigue results are less certain. Needs strict clean-needle technique and your team’s OK when counts are low.
Herbal medicine No herb or supplement treats leukemia or keeps it from coming back. Cost estimate being researched. Real risks: St. John’s wort can weaken imatinib and interacts with other leukemia drugs; grapefruit must be avoided with several; antioxidants may interfere with chemotherapy. Tell your team about everything you take.
Massage therapy Gentle massage for comfort, stress and anxiety during and after treatment, from a therapist experienced with cancer care. One national chain: $125–$160 for 60 minutes (nonmember); prices vary by location. Limited, low-quality evidence for pain and anxiety. Check platelets first; no pressure on ports or lines.
MBHA Wellness Coach Infection precautions, eating well and food safety, fatigue and activity, school re-entry for children, survivorship care plans and emotional support. Coaching: cost estimate being researched. Many support groups are free. Practical help living through long treatment and follow-up. Supports — never replaces — your oncology care.

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Conventional medicine (AMA)

Treatment depends on the type of leukemia, how severe it is, your age and overall health (MedlinePlus (opens in a new tab)), and whether it is new, in remission or has come back (National Cancer Institute (opens in a new tab)). Children are cared for by a pediatric oncologist (NCI (opens in a new tab)). We don’t list doses or schedules — your team sets them.

1. Acute leukemias (ALL and AML): chemotherapy in phases

Treatment usually starts with remission induction, to kill leukemia cells in the blood and marrow, followed by consolidation to kill cells that remain (NCI (opens in a new tab)). Children with ALL also have a maintenance phase, and taking medicine as ordered then lowers the chance the leukemia comes back (NCI (opens in a new tab)). Because leukemia cells can hide in the brain and spinal cord, treatment usually includes chemotherapy into the spinal fluid (intrathecal) and sometimes radiation to the brain (NCI (opens in a new tab)).

  • AML treatment depends on the subtype: chemotherapy, sometimes with targeted drugs matched to gene changes, or gentler options for people who can’t have intensive chemotherapy. Acute promyelocytic leukemia, a subtype that can cause severe bleeding, is treated with all-trans retinoic acid and arsenic trioxide (NCI (opens in a new tab)).
  • Philadelphia chromosome–positive ALL may be treated with a targeted drug such as imatinib, sometimes with chemotherapy (NCI (opens in a new tab)).

2. Immunotherapy for ALL: blinatumomab and CAR T cells

  • Blinatumomab brings the body’s T cells and leukemia cells together so the T cells can kill the leukemia (NCI (opens in a new tab)). It is used for ALL that has come back (NCI (opens in a new tab)), and ACS reports that adding it to chemotherapy showed better outcomes for some children with ALL (ACS (opens in a new tab)).
  • CAR T-cell therapy re-engineers a patient’s own T cells to attack the cancer. The first was approved in 2017 for children with ALL; it eliminated leukemia in most children with relapsed ALL in trials, and many have stayed cancer-free for years. Serious side effects include very high fevers with drops in blood pressure (cytokine release syndrome) and nerve problems such as confusion (NCI (opens in a new tab)).

3. CML: tyrosine kinase inhibitors (TKIs)

Targeted pills that block the abnormal protein are usually the first treatment for CML (American Cancer Society (opens in a new tab)). Imatinib was the first such drug; others include dasatinib, nilotinib, bosutinib, ponatinib and asciminib. Most people need to keep taking a TKI to stay in remission, though some with very good, lasting responses may be able to stop or lower the dose; taking them exactly as directed matters (ACS (opens in a new tab)). A stem cell transplant is an option if TKIs stop working (NHS (opens in a new tab)).

4. CLL: watch-and-wait, then targeted drugs

Early CLL that causes no symptoms is often watched closely without treatment. ACS says treating it right away doesn’t seem to help people live longer, some people never need treatment, and research has found no harm from waiting; blood counts and exams are checked regularly (ACS (opens in a new tab)). When treatment is needed, targeted drugs are often first (ACS (opens in a new tab)): BTK inhibitors (ibrutinib, acalabrutinib, zanubrutinib, pirtobrutinib) and the BCL-2 inhibitor venetoclax, sometimes with an antibody such as obinutuzumab (ACS (opens in a new tab)). BTK inhibitors can cause bleeding, serious infections and heart rhythm problems (ACS (opens in a new tab)). The NHS says CLL can’t be cured but treatment can control it, sometimes for years (NHS (opens in a new tab)).

5. Stem cell transplant and clinical trials

In a stem cell transplant, high-dose chemotherapy (sometimes with whole-body radiation) is followed by an infusion of stem cells from the patient or a donor, which rebuild the blood (NCI (opens in a new tab)). In children it is rarely the first treatment for ALL and is used more often if it comes back (NCI (opens in a new tab)). For some people a clinical trial may be the best choice, and NCI’s clinical trial search lists NCI-supported trials (NCI (opens in a new tab)).

What it costs

Cost estimate being researched. Ask a hospital financial counselor or social worker early; groups such as the HealthWell Foundation and the Leukemia and Lymphoma Society offer financial help (NCI (opens in a new tab)).

How well it works — what to expect

Medical treatment is what puts leukemia into remission or keeps it under control; results differ by type (see Outlook by type above). Follow-up continues after treatment — see Late effects and survivorship.

Find a medical doctor in our directory

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Chiropractic

Chiropractic care has no role in treating leukemia. No complementary approach has been shown to cure cancer (NCCIH, U.S. National Institutes of Health (opens in a new tab)), and a systematic review of chiropractic care for people with cancer found mostly case reports and commentaries, concluding that the field needs further research (Integrative Cancer Therapies, 2012 (opens in a new tab)). We found little research on chiropractic care in people with leukemia. The chance of a serious side effect from spinal manipulation may be greater in people with underlying health problems (NCCIH (opens in a new tab)).

MBHA caution: get your oncologist’s OK first. No source we found sets rules for chiropractic care in leukemia, so these are MBHA’s own precautions, based on these facts:

What it costs

A self-pay follow-up visit is about $55–$100, and a first appointment commonly about $90–$200 (The Pricer (opens in a new tab)).

Find a chiropractor in our directory

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Acupuncture

Acupuncture is used alongside leukemia treatment to ease side effects — not to treat the leukemia itself (National Cancer Institute (opens in a new tab)).

What the research shows

  • Nausea and vomiting: the strongest evidence for acupuncture in cancer care comes from trials for nausea and vomiting; a 2013 review of 41 trials found it helped chemotherapy-related nausea and vomiting (NCI (opens in a new tab)). Much of this research came before current anti-nausea guidelines, so it’s uncertain how much acupuncture adds to today’s medicines (NCCIH (opens in a new tab)). Keep taking the anti-nausea medicines your team prescribes.
  • Fatigue: a 2018 review of 10 studies suggested acupuncture may be more helpful than sham acupuncture or usual care for cancer-related fatigue (NCCIH (opens in a new tab)).
  • We found little research on acupuncture specifically in people with leukemia.

Staying safe

What it costs

Cash-pay follow-up visits run about $90–$185, first visits up to about $125–$230, and community acupuncture about $50–$90 (The Pricer (opens in a new tab)).

Find an acupuncturist in our directory

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Herbal medicine

No herb or supplement treats leukemia. There are no studies proving that any special diet, food, vitamin, mineral, dietary supplement or herb can slow cancer, cure it or keep it from coming back — and some can change how cancer treatment works (National Cancer Institute (opens in a new tab)). Never use one to replace or delay treatment.

Interactions with leukemia drugs

Tell your oncology team about everything

Give your team an up-to-date list of everything you take, including vitamins and herbs, and check before starting anything new (ACS (opens in a new tab)). After treatment, keep telling your doctors about any new vitamins, herbs or supplements (NCI (opens in a new tab)). We don’t list doses here.

What it costs

Cost estimate being researched.

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Massage therapy

Massage can help some people feel calmer and more comfortable during cancer care, but it does not treat leukemia. With appropriate precautions, massage can be part of supportive care for people with cancer, though the evidence that it relieves pain and anxiety is not strong (NCCIH (opens in a new tab)).

What the research shows

  • A 2016 review of 19 studies found some evidence that massage might help with pain and anxiety in people with cancer, but the evidence was very low quality and inconsistent (NCCIH (opens in a new tab)).
  • We found little research on massage specifically for people with leukemia.

Staying safe

  • Low platelets: you may bruise or bleed easily (NCI (opens in a new tab)) — check your counts with your care team before any massage, and ask for light touch. Therapists may need to use less pressure in areas made sensitive by cancer or its treatment (NCCIH (opens in a new tab)). Serious side effects are rare; some reported cases involved vigorous massage or people at higher risk of injury (NCCIH (opens in a new tab)).
  • MBHA caution — no pressure on ports, central lines or swollen lymph nodes. This is our own precaution. Redness, soreness or swelling around a port is a sign of infection to report right away (CDC (opens in a new tab)).
  • Low white cells: stay away from people who are sick (NCI (opens in a new tab)) — reschedule if your therapist has a cold.

What it costs

As one example from a national chain, three locations list a 60-minute massage at $125–$160 for nonmembers, and memberships run about $70–$90 a month; prices vary by location (The Pricer (opens in a new tab)). Massage from a therapist trained in cancer care may cost differently.

Find a massage therapist in our directory

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MBHA Wellness Coach

An MBHA Wellness Coach works alongside your oncology team on everyday life during and after treatment — never as a substitute for medical care.

Infection precautions and eating well

Fatigue and activity

More than 80% of people getting chemotherapy or radiation have fatigue that rest doesn’t fully relieve; a fatigue diary helps your team find causes (NCI (opens in a new tab)). Exercise is safe and helpful for most people — if very tired, start with 10 minutes of light activity a day — but avoid public gyms and crowds while infection risk is high (ACS (opens in a new tab)). See our Chronic Fatigue guide.

Back to school for children

Staying connected to school helps children keep learning and feel normal. Options include home or hospital teaching and Individualized Education Programs (IEPs) or 504 plans. Plan the return early with the care team and the school, and give the school a list of medicines, warning signs and emergency contacts (American Cancer Society (opens in a new tab)).

Survivorship plans and emotional support

Ask for a written treatment summary to share with every doctor (NCI (opens in a new tab)). Living with a leukemia that may come back can be hard, and support from family, friends or a support organization can help (NHS (opens in a new tab)). Ask your hospital social worker or nurse about resources (NCI (opens in a new tab)); support groups can help you feel less alone (NCI (opens in a new tab)). See our Depression and Anxiety guides. In a crisis, call or text 988 (988 Suicide & Crisis Lifeline (opens in a new tab)).

What it costs

Wellness coaching: MBHA cost estimate being researched. Many support groups are free, though some charge a small fee (NCI (opens in a new tab)).

Another approach

Late effects and survivorship

Because treatment has improved so much, most children treated for leukemia will live long lives, and watching for late effects as they grow up is a vital part of their care (American Cancer Society (opens in a new tab)). Late effects are problems that start 6 months or more after treatment and can last for years (National Cancer Institute (opens in a new tab)). After childhood leukemia they can include:

  • Second cancers. A small risk of AML after certain chemotherapy drugs (ACS (opens in a new tab)), and other second cancers such as brain tumors and thyroid cancer (NCI (opens in a new tab)).
  • Heart problems from anthracycline drugs such as doxorubicin; some survivors need heart ultrasounds (echocardiograms) (ACS (opens in a new tab)).
  • Learning and memory. Brain radiation and some chemotherapy, such as intrathecal treatment, may affect learning, and children may need extra support in school (ACS (opens in a new tab)). Children younger than 4 who had brain radiation are at higher risk (NCI (opens in a new tab)).
  • Growth, hormones and fertility. Treatment can slow growth (TKIs for CML can too), affect thyroid and other hormones, and affect fertility; ask about fertility preservation before treatment (ACS (opens in a new tab)).
  • Bones and nerves. Steroids can thin the bones, and vincristine can cause numbness or tingling (ACS (opens in a new tab)).
  • Mental health. Childhood cancer survivors are more likely to have depression, anxiety and post-traumatic stress, so follow-up should include screening for distress (NCI (opens in a new tab)).

Follow-up and your survivorship care plan

  • Visits are usually monthly in the first year after childhood leukemia, then less often for at least 5 years, then at least yearly. ALL and AML most often come back during treatment or within about a year after (ACS (opens in a new tab)).
  • A survivorship care plan should summarize the diagnosis and treatment, set a schedule of follow-up tests, and list late effects to watch for (ACS (opens in a new tab)). Doctors can use the Children’s Oncology Group long-term follow-up guidelines to build it (ACS (opens in a new tab)).
  • Lifelong checkups. Childhood cancer survivors should have an exam at least once a year by someone who knows their late-effect risks. Healthy habits such as a good diet and exercise may make late effects less severe, while smoking or excess alcohol may worsen treatment-related organ damage (NCI (opens in a new tab)).

Member stories

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Sources

This page is for education only and is not medical advice. Costs are typical U.S. ranges and estimates; yours will depend on your provider, location and insurance. Talk with your doctor before starting, stopping or combining any treatment. In an emergency, call 911. See our disclaimer.

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