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Canker Sores
Small, painful sores inside the mouth that aren’t contagious and usually heal on their own within a week or two. Knowing your triggers can mean fewer of them — and sores that keep coming back, or one that won’t heal, deserve a check with your dentist or doctor.
What are canker sores?
A canker sore is a painful, open sore inside the mouth. It is white or yellow in the middle with a bright red border, and it is not cancer (MedlinePlus (opens in a new tab)). The medical name is aphthous ulcer, and when they keep coming back doctors call it recurrent aphthous stomatitis (Cleveland Clinic (opens in a new tab), Merck Manual (opens in a new tab)). They can be quite painful, but they aren’t contagious (MedlinePlus (opens in a new tab)). They usually show up on the soft, moving parts of the mouth: inside the lips and cheeks, on or under the tongue, and at the base of the gums (Cleveland Clinic (opens in a new tab), MedlinePlus (opens in a new tab)). Many people feel burning or tingling a day or so before a sore appears (Cleveland Clinic (opens in a new tab), Merck Manual (opens in a new tab)).
Three types
- Minor — by far the most common. Usually smaller than 1 centimeter (smaller than a pea), and they heal in one to two weeks without scarring (Cleveland Clinic (opens in a new tab), American Academy of Family Physicians (opens in a new tab)).
- Major — bigger, deeper and more painful. They can take weeks or even months to heal and may leave scars (Cleveland Clinic (opens in a new tab), American Academy of Family Physicians (opens in a new tab)).
- Herpetiform — rare. Clusters of tiny pinpoint sores that can merge, usually healing in about two weeks without scarring. Despite the name, they are not caused by herpes (Cleveland Clinic (opens in a new tab), American Academy of Family Physicians (opens in a new tab)).
How common are they?
Very common. Recurrent canker sores are the most common condition of the lining of the mouth; a 2023 review puts the share of people affected at between 5% and 25%, peaking in the teens (review, Medicina Clínica (opens in a new tab)). They are most common in teens and people in their 20s, and more common in women than men. It is unusual to get your first canker sore after age 40 (Cleveland Clinic (opens in a new tab)). They can run in families (MedlinePlus (opens in a new tab)). Some people get one or two sores a few times a year; others have almost constant outbreaks, and attacks usually ease with age (Merck Manual (opens in a new tab)).
What causes them?
Nobody knows exactly. Experts think the immune system plays a part, genes may make some people more prone, and a range of things can set a sore off (Cleveland Clinic (opens in a new tab), American Dental Association (opens in a new tab)). Common triggers include:
- Minor injury inside the mouth — biting your cheek or tongue, brushing too hard, dental work, or rubbing from braces, dentures, a rough filling or a sharp tooth (MedlinePlus (opens in a new tab), NHS (opens in a new tab)).
- Toothpaste with sodium lauryl sulfate (SLS), a foaming ingredient (Cleveland Clinic (opens in a new tab), NHS (opens in a new tab)).
- Certain foods and drinks — acidic or spicy foods, caffeine, and for some people eggs, cheese, chocolate, peanuts or almonds (Cleveland Clinic (opens in a new tab), Merck Manual (opens in a new tab)), and food allergies or intolerances (MedlinePlus (opens in a new tab), NHS (opens in a new tab)) — though Merck says allergic reactions don’t seem to be involved (Merck Manual (opens in a new tab)).
- Stress, anxiety and tiredness — Merck gives the example of a college student who gets sores during final-exam week (Merck Manual (opens in a new tab), NHS (opens in a new tab)).
- Hormone changes, such as around a period or in pregnancy (Cleveland Clinic (opens in a new tab), NHS (opens in a new tab)).
- Low levels of nutrients — especially iron, folic acid (folate) and vitamin B12, and also vitamin D and zinc (MedlinePlus (opens in a new tab), Cleveland Clinic (opens in a new tab)).
- Some medicines, including NSAID pain relievers, beta-blockers and immunosuppressants (Cleveland Clinic (opens in a new tab), NHS (opens in a new tab)). Don’t stop a prescribed medicine on your own — ask the prescriber.
- Stopping smoking — some people get mouth ulcers when they first quit (NHS (opens in a new tab)). That is no reason to go back to smoking.
How long do they last?
The pain usually eases within a few days, and most sores heal within two weeks without any treatment (Cleveland Clinic (opens in a new tab)). MedlinePlus says the pain often goes in 7 to 10 days and a sore can take 1 to 3 weeks to heal completely, with large ulcers taking longer (MedlinePlus (opens in a new tab)). Major sores may take up to six weeks or more (American Academy of Family Physicians (opens in a new tab), Cleveland Clinic (opens in a new tab)).
Canker sore or cold sore?
They are often confused, but they are different conditions (MedlinePlus (opens in a new tab), NHS (opens in a new tab)):
- Cause: canker sores are not caused by a virus, and the exact cause is unknown (American Academy of Family Physicians (opens in a new tab)). Cold sores (fever blisters) are caused by the herpes simplex virus, usually HSV-1 (MedlinePlus (opens in a new tab)).
- Catching: canker sores are not contagious (Cleveland Clinic (opens in a new tab)). Cold sores spread easily, especially through close contact or shared items such as razors, towels and dishes while a sore is active (MedlinePlus (opens in a new tab)).
- Where: canker sores form inside the mouth on soft tissue. Cold sores usually appear on the outside of the lips or the corners of the mouth (American Academy of Family Physicians (opens in a new tab), NHS (opens in a new tab)), though they can also show up inside the mouth as a small group of pinhead-sized ulcers (NHS (opens in a new tab)).
- What they look like: a canker sore is a shallow ulcer from the start — there is never a blister (Merck Manual (opens in a new tab)). Cold sores start as small fluid-filled blisters that break, leak and then crust over as they heal (MedlinePlus (opens in a new tab)).
- Treatment: cold sores can be treated with prescription antiviral medicines, which work best when started at the first tingle (MedlinePlus (opens in a new tab)). Antivirals aren’t used for canker sores. Because steroids can make a herpes infection worse, a clinician will make sure a sore isn’t herpes before prescribing one (Merck Manual (opens in a new tab)).
When mouth ulcers keep coming back
Most canker sores are just canker sores. But frequent or unusual mouth ulcers can sometimes be a sign of something else, and the list of possible causes is long — from inherited fever syndromes to inflammatory bowel disease (review, Journal of Clinical and Aesthetic Dermatology (opens in a new tab)). If your sores keep returning, a clinician may order tests, including blood tests, to look for a cause (MedlinePlus (opens in a new tab), Cleveland Clinic (opens in a new tab)). Conditions linked to mouth ulcers include:
- Celiac disease — canker sores, a dry mouth, or a red, smooth, shiny tongue can be symptoms (NIDDK (opens in a new tab)). See our Celiac Disease guide.
- Crohn’s disease and other inflammatory bowel disease (NHS (opens in a new tab), Cleveland Clinic (opens in a new tab)).
- Low vitamin B12, iron or folate. Mouth ulcers are listed among the symptoms of iron-deficiency anemia and of folate deficiency (MedlinePlus (opens in a new tab), MedlinePlus (opens in a new tab)), and low B12 can cause a swollen, red tongue (MedlinePlus (opens in a new tab)). Celiac and Crohn’s can themselves make it harder to absorb iron and B12 (MedlinePlus (opens in a new tab), MedlinePlus (opens in a new tab)).
- Behçet’s disease — painful mouth sores that look like ordinary canker sores are usually its first sign, and about 3 in 4 people with it also get similar sores on the genitals (MedlinePlus Genetics (opens in a new tab)). The NHS advises seeing a doctor if you have mouth ulcers along with ulcers on your skin or genitals, or painful, red or swollen joints (NHS (opens in a new tab)). See our Behçet’s Disease guide.
- HIV and other causes of a weakened immune system, such as lupus (NHS (opens in a new tab), Cleveland Clinic (opens in a new tab)). Canker sores are among the most common mouth problems in people with HIV (NIDCR (opens in a new tab)), and people with advanced HIV often have large canker sores that last for weeks (Merck Manual (opens in a new tab)). See our HIV & AIDS guide.
See a dentist or doctor if:
- A sore hasn’t healed after 2 weeks of home care, or is getting worse (MedlinePlus (opens in a new tab), Cleveland Clinic (opens in a new tab)). The NHS uses 3 weeks as its cut-off for any mouth ulcer (NHS (opens in a new tab)).
- A sore is unusually large — bigger than about 1 centimeter (a pea) — or different from sores you’ve had before, for example near the back of your throat (Cleveland Clinic (opens in a new tab), NHS (opens in a new tab)).
- You have a fever or other symptoms with the sores, such as flu-like illness, diarrhea, headache or a skin rash (MedlinePlus (opens in a new tab), Cleveland Clinic (opens in a new tab)).
- It hurts too much to eat or drink (American Academy of Family Physicians (opens in a new tab), Cleveland Clinic (opens in a new tab)).
- You get them often — more than 2 or 3 times a year (MedlinePlus (opens in a new tab), American Academy of Family Physicians (opens in a new tab)).
- A sore bleeds, or becomes more painful and red, which may mean infection (NHS (opens in a new tab)).
- You also have ulcers elsewhere (skin or genitals), or painful, swollen joints (NHS (opens in a new tab)).
- A sore, red or white patch, lump, or thick or rough spot in your mouth doesn’t go away. Canker sores don’t cause cancer, but some cancers first look like a mouth ulcer that doesn’t heal (MedlinePlus (opens in a new tab)). The American Dental Association and NIDCR advise seeing a dentist or doctor if any of these lasts longer than two weeks (American Dental Association (opens in a new tab), NIDCR (opens in a new tab)), and the American Cancer Society lists a sore on the lip or in the mouth that doesn’t heal among the signs of mouth cancer (American Cancer Society (opens in a new tab)).
Side by side
Six approaches compared
For every condition we look at the same six approaches: what each involves, what it typically costs, and what a patient can realistically expect.
| Approach | What it involves | Estimated cost | What to expect |
|---|---|---|---|
| Conventional medicine (AMA) | Over-the-counter numbing gels, protective patches and pastes, and alcohol-free or antiseptic rinses; prescription steroid or chlorhexidine rinses and ointments; tests for an underlying cause when sores keep returning; laser or cautery for severe sores. | At one pharmacy: a mouth-sore pain-relief gel about $6, a canker-sore patch pack about $10, a mouth-sore rinse about $12. Dental or doctor visit: cost estimate being researched. | Treatment eases pain and may speed healing; most sores heal within two weeks either way. No benzocaine products for children under 2. Frequent sores deserve a look for a cause. |
| Chiropractic | Being researched — coming soon. | ||
| Acupuncture | Being researched — coming soon. | ||
| Herbal medicine | Licorice (including dissolving patches and rinses), aloe vera gel, honey and chamomile applied in the mouth. | At one pharmacy: an aloe-containing canker gel about $5. | Small studies suggest licorice and aloe may ease pain or shrink sores; evidence for honey and chamomile is mixed. Licorice can interact with steroids. Never give honey to a baby under 1. |
| Massage therapy | Being researched — coming soon. | ||
| MBHA Wellness Coach | A soft toothbrush and gentle brushing, an SLS-free toothpaste trial, a trigger-food and stress diary, salt-water rinses, iron-, folate- and B12-rich meals, and tracking outbreaks to share with your clinician. | Cost estimate being researched. | Knowing your triggers may mean fewer and milder sores. A coach supports you; a coach never replaces a check for sores that won’t heal or keep coming back. |
Approach 1 of 6
Conventional medicine (AMA)
Most canker sores go away without treatment (MedlinePlus (opens in a new tab)). The aim of treatment is to ease the pain while the sore heals, help it heal a little faster where possible, and look for a cause when sores keep coming back (American Academy of Family Physicians (opens in a new tab), Cleveland Clinic (opens in a new tab)).
1. Over-the-counter relief
- Numbing gels and liquids. Most canker-sore products contain a numbing agent, and some also protect the sore from irritation while you eat, drink and brush (American Academy of Family Physicians (opens in a new tab)). Benzocaine is a common one, found in brands such as Orajel and Anbesol (Cleveland Clinic (opens in a new tab)).
- Protective products, such as patches and pastes, help shield the sore from irritation. Ask your doctor or pharmacist which one may be right for you (American Academy of Family Physicians (opens in a new tab)).
- Mouth rinses. Salt water or a mild, alcohol-free mouthwash can ease pain; avoid mouthwashes with alcohol, which can irritate the sore more (MedlinePlus (opens in a new tab), Cleveland Clinic (opens in a new tab)). The American Dental Association notes that antimicrobial mouthwashes may give temporary relief (American Dental Association (opens in a new tab)).
- Ordinary pain relievers can also help (American Academy of Family Physicians (opens in a new tab)). Follow the label, and ask your pharmacist if you take other medicines.
Benzocaine and young children. The FDA says over-the-counter mouth products containing benzocaine should not be used in children under 2 years old, under any circumstances, and should not be used for teething. Benzocaine can cause methemoglobinemia, a serious and sometimes fatal condition in which the blood carries much less oxygen. It can happen after a single use, even in someone who has used benzocaine before without trouble (FDA (opens in a new tab), FDA (opens in a new tab)). Get medical help right away if anyone — child or adult — develops pale, gray or blue skin, shortness of breath, tiredness, headache, light-headedness or a racing heart after using it (FDA (opens in a new tab)).
2. Prescription treatment
For severe or frequent sores, a dentist or doctor may prescribe (MedlinePlus (opens in a new tab), Cleveland Clinic (opens in a new tab), Merck Manual (opens in a new tab)):
- Steroid ointments, pastes or rinses placed directly on the sores, such as fluocinonide, clobetasol or dexamethasone, and steroid tablets (such as prednisone) only if those don’t work. A clinician first makes sure the sore isn’t herpes, and keeps an eye out for thrush (a yeast infection), which steroids can bring on (Merck Manual (opens in a new tab)).
- Chlorhexidine mouthwash, an antiseptic rinse; Merck notes it may reduce how often sores come back, though it isn’t the main treatment (Merck Manual (opens in a new tab)).
- Other prescription rinses, sometimes called “magic mouthwash” (Cleveland Clinic (opens in a new tab)), and antibiotics from your dentist, which can reduce the chance of a secondary infection (American Dental Association (opens in a new tab)).
- Laser therapy or electrocautery for severe sores, to reduce pain and speed healing (Cleveland Clinic (opens in a new tab)).
3. Looking for a cause
If sores persist or keep returning, a clinician may check for other causes, sometimes with blood tests or a small sample (biopsy) of the sore (MedlinePlus (opens in a new tab), American Academy of Family Physicians (opens in a new tab)). If a test shows low iron, folate or vitamin B12, treating that deficiency is part of the plan (Cleveland Clinic (opens in a new tab)); your provider will usually measure your iron level before you start iron pills (MedlinePlus (opens in a new tab)). If another condition is behind the sores, treating it can help (MedlinePlus (opens in a new tab)).
Who to see
Your dentist or primary care provider is a good first stop: most of the time they can tell what a mouth ulcer is by looking at it (MedlinePlus (opens in a new tab)). Your dental team also checks for signs of mouth cancer at each visit (American Dental Association (opens in a new tab)).
What it costs
- Orajel mouth sore pain-relief gel: about $6 for 0.18 oz (retail listing: Pasteur Pharmacy (opens in a new tab)).
- DenTek canker sore patches: about $10 a pack (retail listing: Pasteur Pharmacy (opens in a new tab)).
- Colgate Peroxyl alcohol-free mouth sore rinse: about $12 for 16.9 oz (retail listing: Pasteur Pharmacy (opens in a new tab)).
- Prices change, and store brands often cost less. Dental and doctor visits, blood tests and prescription treatment: MBHA cost estimate being researched.
How well it works — what to expect
Expect relief rather than a quick fix: canker sores almost always heal on their own, with pain easing in a few days (MedlinePlus (opens in a new tab)), and treatment can speed this up or ease symptoms (American Academy of Family Physicians (opens in a new tab)). A 2026 review of 41 earlier reviews found that steroids applied to the sore and low-level laser therapy consistently reduced pain and shortened healing time, but evidence that any treatment prevents sores from coming back is limited (umbrella review, Journal of Dermatological Treatment (opens in a new tab)). There is no cure for recurring canker sores (American Academy of Family Physicians (opens in a new tab)).
Approach 4 of 6
Herbal medicine
Several plant-based remedies have been tested on canker sores, mostly in small studies. They are worth discussing with your dentist or pharmacist, but none replaces a check-up when the warning signs above apply.
Licorice root
The U.S. National Center for Complementary and Integrative Health (NCCIH) says a licorice mouth rinse or gargle might reduce ulcer size and pain in people with recurring canker sores, while licorice applied to the sore might reduce ulcer size only — though overall there isn’t enough high-quality evidence to clearly support licorice for any condition (NCCIH (opens in a new tab)).
- In a 2008 U.S. trial, sores treated with a dissolving oral patch containing licorice root extract had shrunk significantly by day 8, while untreated sores had grown slightly. By day 4, 81% of the licorice-patch group reported no pain at rest, compared with 63% of the dummy-patch group and 40% of the untreated group. Each group had 23 people (trial, General Dentistry (opens in a new tab)).
- A 2023 review found six trials (314 people) of licorice pastes, patches and mouthwashes. The authors reported less pain, smaller sores and faster healing with no side effects, but the studies were too different to combine statistically (systematic review, Iranian Journal of Medical Sciences (opens in a new tab)).
Safety: licorice contains glycyrrhizin, which can cause serious side effects, including irregular heartbeat, especially in large amounts or over a long time, and even small amounts have caused problems in people with high blood pressure or heart or kidney disease. “DGL” (deglycyrrhizinated licorice) products have the glycyrrhizin removed. Licorice applied to the skin may irritate, and licorice can interact with corticosteroids — worth knowing, since steroids are a common prescription for canker sores. Large amounts are unsafe in pregnancy (NCCIH (opens in a new tab)).
Aloe vera
In a 2022 trial of 60 people aged 15 to 25 in Syria, an aloe vera gel shrank minor canker sores and eased pain more than a dummy gel by day 5, and did better than amlexanox, a medicated paste (trial, Cureus (opens in a new tab)). That is a single small study. Aloe gel on the skin is generally well tolerated, with occasional burning, itching or rash; aloe taken by mouth is a different matter, with possible side effects, a possible interaction with the heart medicine digoxin, and safety concerns in pregnancy and breastfeeding (NCCIH (opens in a new tab)).
Honey
A 2025 trial of 30 people in Egypt found that thyme honey on minor canker sores eased pain and shrank sores more than a standard steroid paste (trial, European Journal of Oral Sciences (opens in a new tab)). A 2025 review that pooled trials found mixed results for honey compared with the steroid, and warned that there were few placebo-controlled trials and that the studies were at moderate to high risk of bias (systematic review, BMC Oral Health (opens in a new tab)). Never give honey to a baby under 1 year old — it can carry the spores that cause infant botulism (MedlinePlus (opens in a new tab)).
Chamomile
In a small 2006 study, most people using a chamomile extract on canker sores and other painful mouth ulcers rated its pain relief as excellent (study, Journal of Drugs in Dermatology (opens in a new tab)). In a 2023 analysis of 43 trials of treatments applied to the sore, no treatment — chamomile included — clearly beat a placebo for pain, although chamomile ranked among the more promising (network meta-analysis, Journal of Oral Pathology and Medicine (opens in a new tab)), and a 2025 review found chamomile did less well than a steroid paste (systematic review, BMC Oral Health (opens in a new tab)). Chamomile can cause allergic reactions, more likely if you’re allergic to ragweed, chrysanthemums, marigolds or daisies, and it may interact with warfarin, some other medicines and birth control pills (NCCIH (opens in a new tab), NCCIH (opens in a new tab)).
The bottom line
A 2026 review of the research found that herbal agents showed favorable short-term results with good safety (umbrella review, Journal of Dermatological Treatment (opens in a new tab)), but most herbal studies are small. Tell your dentist, doctor and pharmacist about every herb or supplement you use, because some herbs and medicines interact in harmful ways (NCCIH (opens in a new tab)). We don’t list strengths or doses here.
What it costs
GUM Canker-X gel, which contains aloe vera and coats the sore: about $5 (retail listing: Pasteur Pharmacy (opens in a new tab)). Other herbal products: cost estimate being researched.
Approach 6 of 6
MBHA Wellness Coach
There is no sure way to prevent canker sores, but noticing and avoiding your own triggers helps many people (Cleveland Clinic (opens in a new tab)). An MBHA Wellness Coach can help you find yours and build gentler habits — alongside, never instead of, your dentist or doctor.
Gentle mouth care
- Use a soft-bristled toothbrush and waxed floss, and brush gently (Cleveland Clinic (opens in a new tab), NHS (opens in a new tab)). Brushing after meals and flossing daily keeps food particles away from sores (American Academy of Family Physicians (opens in a new tab)).
- Keep up regular dental check-ups (NHS (opens in a new tab), MedlinePlus (opens in a new tab)), and ask your dentist to fix anything that rubs, such as braces, dentures, a rough filling or a sharp tooth (NHS (opens in a new tab)).
- Rinsing with salt water, or a mild, alcohol-free mouthwash, can ease pain (MedlinePlus (opens in a new tab), Cleveland Clinic (opens in a new tab), NHS (opens in a new tab)). Spit it out rather than swallowing.
Try an SLS-free toothpaste
Cleveland Clinic and the NHS suggest a toothpaste without sodium lauryl sulfate (Cleveland Clinic (opens in a new tab), NHS (opens in a new tab)). The evidence is encouraging but limited: a 2019 review of four small crossover trials (124 people) found that SLS-free toothpaste reduced the number of ulcers, how long they lasted, how often they came and how much they hurt, while calling for better trials (systematic review, Journal of Oral Pathology and Medicine (opens in a new tab), commentary, Journal of Evidence-Based Dental Practice (opens in a new tab)). Check the ingredient list, or ask your dentist to recommend a brand (Cleveland Clinic (opens in a new tab)). A coach can help you run a fair trial: switch toothpaste and track whether your sores change.
Food and drink
- While a sore heals, skip very spicy, salty or acidic foods, rough or crunchy foods such as toast or chips, and very hot or acidic drinks such as fruit juice. Softer foods and cool drinks through a straw are kinder (NHS (opens in a new tab), Cleveland Clinic (opens in a new tab)). Avoiding chewing gum can help too (American Academy of Family Physicians (opens in a new tab)).
- Keep a simple food diary. Foods reported as triggers for some people include acidic foods, caffeine, eggs, cheese, chocolate, peanuts and almonds (Cleveland Clinic (opens in a new tab), Merck Manual (opens in a new tab)). The aim is to notice your triggers and avoid those (Cleveland Clinic (opens in a new tab)), not to cut out every food on the list.
Eating for iron, folate and vitamin B12
A healthy, balanced diet is part of the NHS self-care advice (NHS (opens in a new tab)). If you get sores often, ask your provider whether a blood test for deficiencies makes sense before taking supplements (Cleveland Clinic (opens in a new tab)). Good food sources include:
- Vitamin B12: fish, meat, poultry, eggs, milk and dairy foods, and some fortified breakfast cereals and nutritional yeasts. B12 isn’t found in plant foods unless they are fortified, so vegetarians and vegans need to plan for it (MedlinePlus (opens in a new tab)). Weight-loss surgery, celiac disease, Crohn’s, long-term use of heartburn medicines or metformin can also lower B12 (MedlinePlus (opens in a new tab)).
- Folate: dark green leafy vegetables, dried beans and peas, citrus fruits, and fortified breads, cereals and pastas (MedlinePlus (opens in a new tab)).
- Iron: meat, poultry, fish, lentils, beans, chickpeas, whole-grain bread, oatmeal and leafy greens. Vitamin C foods such as oranges, strawberries, broccoli and tomatoes help your body absorb iron (MedlinePlus (opens in a new tab)).
Stress and rest
Stress and tiredness are common triggers (NHS (opens in a new tab), Merck Manual (opens in a new tab)). Cleveland Clinic suggests stress-reduction techniques such as mindfulness and meditation (Cleveland Clinic (opens in a new tab)). A coach can help you build a routine you’ll keep — especially around exams, deadlines or other busy times.
Track your outbreaks
Note when each sore appears, how big it is, how long it lasts, and what was going on — foods, stress, your menstrual cycle, a bitten cheek, a new medicine. Bring the log to your dentist or doctor: getting sores more than 2 or 3 times a year, or sores that come with other symptoms, is a reason to look for a cause (MedlinePlus (opens in a new tab)).
Still being researched: Chiropractic, Acupuncture, Massage therapy. We add each approach once its costs and results are sourced. Are you a practitioner with experience treating Canker Sores? Tell us.
Member stories
Living with Canker Sores? Share your experience
Real experiences help others choose. Tell us what you tried — conventional medicine, chiropractic, acupuncture, herbs, massage or coaching — what it cost and what changed.
Sources
- MedlinePlus — Canker sore (opens in a new tab)
- MedlinePlus — Canker sores (health topic) (opens in a new tab)
- MedlinePlus — Mouth ulcers (opens in a new tab)
- MedlinePlus — Herpes, oral (cold sores) (opens in a new tab)
- MedlinePlus — Vitamin B12 (opens in a new tab)
- MedlinePlus — Anemia due to vitamin B12 deficiency (opens in a new tab)
- MedlinePlus — Folic acid in diet (opens in a new tab)
- MedlinePlus — Iron deficiency anemia (opens in a new tab)
- MedlinePlus — Infant botulism (opens in a new tab)
- MedlinePlus Genetics — Behçet disease (opens in a new tab)
- Cleveland Clinic — Canker sores (opens in a new tab)
- American Academy of Family Physicians (familydoctor.org) — Canker sores (opens in a new tab)
- Merck Manual Consumer Version — Recurrent aphthous stomatitis (opens in a new tab)
- NHS — Mouth ulcers (opens in a new tab)
- American Dental Association, MouthHealthy — Canker sores (opens in a new tab)
- American Dental Association, MouthHealthy — Oral cancer (opens in a new tab)
- National Institute of Dental and Craniofacial Research (NIDCR) — Oral cancer (opens in a new tab)
- NIDCR — HIV, AIDS and oral health (opens in a new tab)
- American Cancer Society — Signs and symptoms of oral cavity and oropharyngeal cancers (opens in a new tab)
- NIDDK — Symptoms and causes of celiac disease (opens in a new tab)
- FDA — Letter to manufacturers on OTC oral health care products containing benzocaine (May 2018, PDF) (opens in a new tab)
- FDA — Safely soothing teething pain and sensory needs in babies and older children (opens in a new tab)
- NCCIH — Licorice root (opens in a new tab)
- NCCIH — Aloe vera (opens in a new tab)
- NCCIH — Chamomile (opens in a new tab)
- NCCIH — Herb-drug interactions: what the science says (opens in a new tab)
- Conejero Del Mazo et al. — Recurrent aphthous stomatitis, Medicina Clínica, 2023 (PubMed abstract) (opens in a new tab)
- Edgar et al. — Recurrent aphthous stomatitis: a review, Journal of Clinical and Aesthetic Dermatology, 2017 (PubMed abstract) (opens in a new tab)
- Al-Aizari et al. — Evidence-based recommendations for the treatment of recurrent aphthous stomatitis: an umbrella review, Journal of Dermatological Treatment, 2026 (PubMed abstract) (opens in a new tab)
- Mashrah et al. — Topical medications for the treatment of recurrent aphthous stomatitis: a network meta-analysis, Journal of Oral Pathology and Medicine, 2023 (PubMed abstract) (opens in a new tab)
- Al-Zaghruri et al. — Systematic review and meta-analysis comparing triamcinolone acetonide with other therapies for minor recurrent aphthous stomatitis, BMC Oral Health, 2025 (PubMed abstract) (opens in a new tab)
- Alli et al. — Effect of sodium lauryl sulfate on recurrent aphthous stomatitis: a systematic review, Journal of Oral Pathology and Medicine, 2019 (PubMed abstract) (opens in a new tab)
- Cheng — Limited evidence suggests that patients with recurrent aphthous stomatitis may benefit from using sodium lauryl sulfate-free dentifrices, Journal of Evidence-Based Dental Practice, 2019 (PubMed) (opens in a new tab)
- Martin et al. — A controlled trial of a dissolving oral patch concerning glycyrrhiza (licorice) herbal extract for the treatment of aphthous ulcers, General Dentistry, 2008 (PubMed abstract) (opens in a new tab)
- Dorsareh et al. — Topical licorice for aphthous: a systematic review of clinical trials, Iranian Journal of Medical Sciences, 2023 (PubMed abstract) (opens in a new tab)
- Yousef et al. — Aloe vera versus amlexanox in the treatment of recurrent aphthous ulcers: a three-arm placebo-controlled randomized clinical trial, Cureus, 2022 (PubMed abstract) (opens in a new tab)
- Ghalwash et al. — Efficacy of thyme honey in the management of oral aphthous ulcers: a randomized controlled clinical trial, European Journal of Oral Sciences, 2025 (PubMed abstract) (opens in a new tab)
- Ramos-e-Silva et al. — Clinical evaluation of fluid extract of Chamomilla recutita for oral aphthae, Journal of Drugs in Dermatology, 2006 (PubMed abstract) (opens in a new tab)
- Pasteur Pharmacy — Orajel mouth sore pain relief gel (price listing) (opens in a new tab)
- Pasteur Pharmacy — DenTek canker sore patches (price listing) (opens in a new tab)
- Pasteur Pharmacy — Colgate Peroxyl mouth sore rinse (price listing) (opens in a new tab)
- Pasteur Pharmacy — GUM Canker-X gel with aloe vera (price listing) (opens in a new tab)
This page is for education only and is not medical advice. Costs are typical U.S. ranges and estimates; yours will depend on your provider, location and insurance. Talk with your doctor before starting, stopping or combining any treatment. In an emergency, call 911. See our disclaimer.
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