Home / Health Conditions / Endometriosis
Endometriosis
Endometriosis is a common, long-lasting condition in which tissue similar to the lining of the uterus grows outside it. It can cause painful periods, pelvic pain and trouble getting pregnant. There is no cure yet, but many treatments can ease the pain and help with fertility — and severe period pain is never something you just have to put up with.
Call 911 or go to the emergency room if you have:
- Sudden, severe pain in your lower belly or pelvis, especially with fever and vomiting, faintness, dizziness or weakness, or fast breathing. An ovarian cyst may have burst (ruptured) or twisted the ovary (torsion); large ruptured cysts can cause heavy bleeding (Office on Women’s Health (opens in a new tab)). Endometriosis can form cysts on the ovaries, called endometriomas (NICHD (opens in a new tab), Office on Women’s Health (opens in a new tab)).
- A positive pregnancy test (or a chance you could be pregnant) with sudden, severe belly or pelvic pain, shoulder pain, or feeling very dizzy or faint. These can be signs of a ruptured ectopic pregnancy — one growing outside the uterus, usually in a fallopian tube — which can cause life-threatening internal bleeding (MedlinePlus (opens in a new tab), NHS (opens in a new tab)).
Get care the same day (your clinician, urgent care or the ER) for:
- Any pain or bleeding with a positive pregnancy test, even if mild. Light vaginal bleeding and pelvic pain can be early signs of an ectopic pregnancy (MedlinePlus (opens in a new tab)), so get advice right away (NHS (opens in a new tab)).
- Very heavy bleeding — bleeding through one or more pads or tampons every one to two hours (Office on Women’s Health (opens in a new tab)). Feeling dizzy, lightheaded or weak during or after your period is a reason to call your doctor (Office on Women’s Health (opens in a new tab)); if you feel faint, go to the ER.
Don’t assume sudden, severe new pain is “just my endometriosis,” and don’t wait for a complementary-care appointment for any of these signs.
What is endometriosis?
Endometriosis (“endo”) is a disease in which tissue similar to the lining of the uterus (the endometrium) grows in other places in the body (NICHD (opens in a new tab), Office on Women’s Health (opens in a new tab)). It is most often found on the ovaries, fallopian tubes, the tissues that hold the uterus in place and the outside of the uterus, and can also grow on the bowel, bladder or rectum (Office on Women’s Health (opens in a new tab)). It is a chronic (long-lasting) condition (WHO (opens in a new tab)).
The growths respond to hormones and can bleed around each period, irritating nearby tissue and causing inflammation and scar tissue (adhesions) that can make organs stick together (NICHD (opens in a new tab), Office on Women’s Health (opens in a new tab)). On the ovaries they can form cysts called endometriomas, which can be painful during sex and during your period (Office on Women’s Health (opens in a new tab)); see our Cysts guide.
How common? About 1 in 10 women of reproductive age have it — an estimated 190 million worldwide (WHO (opens in a new tab)). It can also affect transgender men and non-binary people who menstruate (WHO (opens in a new tab)).
Symptoms
- Painful periods that may get worse over time, and long-term pelvic pain (NICHD (opens in a new tab), Office on Women’s Health (opens in a new tab)).
- Pain during or after sex, often a “deep” pain (Office on Women’s Health (opens in a new tab)).
- Pain with bowel movements or urination, especially during periods, and diarrhea, constipation, bloating or nausea (Office on Women’s Health (opens in a new tab)). Some people also have painful bladder syndrome or bowel-disorder-like symptoms (NICHD (opens in a new tab)); see our Bowel Problems and Bladder Problems guides. An Irritable Bowel guide is coming soon.
- Heavy periods or bleeding between periods (NICHD (opens in a new tab)).
- Infertility and fatigue (NICHD (opens in a new tab)).
The amount of pain doesn’t always match the amount of disease: a few small patches can hurt badly, while large areas may cause little pain, and some people have no symptoms (NICHD (opens in a new tab), WHO (opens in a new tab)).
Causes, and what it is not
No one knows exactly what causes endometriosis. Menstrual tissue flowing backward into the pelvis is one theory, but it doesn’t explain every case (NICHD (opens in a new tab)); genes, the immune system and hormones are also being studied (Office on Women’s Health (opens in a new tab)). It is more likely if your mother, sister or daughter has it, or if your periods started early, your cycles are short, or your periods are heavy and last more than 7 days (NICHD (opens in a new tab)). There is no known way to prevent it (WHO (opens in a new tab)) — it is not something you caused.
It is not cancer. The growths are benign (Office on Women’s Health (opens in a new tab)). Endometriosis is not linked with a significantly higher risk of cancer overall; it is linked with a higher risk of ovarian, breast and thyroid cancer, but the increase in absolute risk is low (ESHRE guideline, 2022 (opens in a new tab)).
Why diagnosis can take years
Symptoms vary and are often dismissed as “normal” period pain. The World Health Organization reports that the average time to diagnosis is between 4 and 12 years (WHO (opens in a new tab)). Period pain that keeps you from normal activities is worth raising — and raising again if it isn’t taken seriously.
How is it diagnosed?
- History and exam, including a pelvic exam (NICHD (opens in a new tab)). Endometriosis symptoms can look like other conditions, such as adenomyosis, fibroids, pelvic inflammatory disease and irritable bowel syndrome (NHS (opens in a new tab)).
- Ultrasound or MRI. The ultrasound may be done inside the vagina or across the belly (Office on Women’s Health (opens in a new tab), NHS (opens in a new tab)). Imaging can find larger areas such as cysts and nodules but not small lesions or scar tissue, so a normal scan doesn’t rule endometriosis out (NICHD (opens in a new tab), ESHRE guideline, 2022 (opens in a new tab)).
- Laparoscopy, a surgery through a small cut, is the only way to confirm it; the surgeon may take a biopsy and remove lesions at the same time (NICHD (opens in a new tab), NHS (opens in a new tab)). You don’t have to have surgery before starting medical treatment (WHO (opens in a new tab)).
Adenomyosis, a related condition
In adenomyosis, uterine-lining tissue grows into the muscle wall of the uterus. It can also cause painful, heavy periods, usually affects women over 35, and is more likely if you have given birth or have endometriosis. Treatment may include a hormonal IUD or other hormonal birth control, NSAIDs or medicine to reduce heavy bleeding, and, if these don’t work, uterine artery embolization or hysterectomy (NHS (opens in a new tab)). Our Female Problems guide, coming soon, will say more.
Side by side
Six approaches compared
For every condition we look at the same six approaches: what each involves, what it typically costs, and what a patient can realistically expect.
| Approach | What it involves | Estimated cost | What to expect |
|---|---|---|---|
| Conventional medicine (AMA) | Pain relievers (NSAIDs); hormonal treatment — combined birth control, progestins including the hormonal IUD, GnRH agonists or GnRH antagonists; laparoscopic surgery to remove (excise) or destroy (ablate) lesions; hysterectomy as a last resort; fertility treatment such as IVF; and pelvic floor physical therapy as part of pain care. | Cost estimate being researched (medicine, imaging, surgery and physical therapy). | There is no cure, but treatments can help manage symptoms. Hormones work only while you take them, pain often returns after surgery, and hysterectomy doesn’t always end the pain. |
| Chiropractic | No role in treating endometriosis. Chiropractic care cannot remove or shrink endometriosis lesions. | Not a treatment for endometriosis, so no cost is listed. | We found no studies of chiropractic care for endometriosis, and reviews found no clear benefit from spinal manipulation for period pain. Don’t let it delay a gynecology visit. |
| Acupuncture | A course of needle sessions for pain, used alongside — not instead of — medical care. | About $125–$230 for a first private visit and $90–$185 for follow-ups; community clinics about $50–$90. | Small trials suggest it may ease period pain during treatment, but in the largest trial the benefit faded after treatment stopped. Evidence is limited, and it doesn’t treat the lesions. |
| Herbal medicine | Chinese herbal medicine and supplements such as turmeric are sometimes tried. None is proven to treat endometriosis. | Cost estimate being researched. | Evidence is limited; a 2025 review found supplements no better than placebo for pain. Some herbs have hormone-like effects or weaken birth control pills. Avoid them while trying to conceive unless your provider agrees. |
| Massage therapy | Relaxing massage, including gentle belly and lower-back massage, as a comfort measure alongside medical care. | At one national chain, memberships run about $70–$90 a month for one 60-minute session. | A few small studies reported less period pain, but the evidence is limited. A pleasant, low-risk extra, not a treatment for the disease. |
| MBHA Wellness Coach | A pain and symptom diary, heat, regular exercise, sleep, realistic eating changes, preparing for appointments, mental health support and connecting with support groups. | Cost estimate being researched. | Supports — never replaces — medical care. Self-care can make pain easier to manage and visits more useful; diet evidence is still limited. |
Approach 1 of 6
Conventional medicine (AMA)
Treatment depends on your symptoms, how severe the disease is, your age and whether you want to get pregnant (NICHD (opens in a new tab), WHO (opens in a new tab)), and some treatments can be used together (Office on Women’s Health (opens in a new tab)). Europe’s specialist guideline asks clinicians to decide with you, weighing side effects, cost and your preferences (ESHRE guideline, 2022 (opens in a new tab)).
Pain relievers (NSAIDs)
NSAIDs such as ibuprofen and naproxen are often used for endometriosis pain (WHO (opens in a new tab)), especially when symptoms are mild (Office on Women’s Health (opens in a new tab)); if you are trying to get pregnant, you won’t be given hormones (NHS (opens in a new tab)). Evidence for endometriosis pain specifically is limited (NICHD (opens in a new tab)). Don’t take NSAIDs if you have ulcers or other stomach problems, bleeding problems or liver disease, or are allergic to aspirin (MedlinePlus (opens in a new tab)).
Hormonal treatments
Hormones can slow lesion growth and ease pain, but they don’t make existing scar tissue go away, don’t work for everyone, and symptoms often return when they stop (NICHD (opens in a new tab)). If you aren’t trying to get pregnant, hormonal birth control is generally the first step (Office on Women’s Health (opens in a new tab)).
- Combined hormonal birth control (pill, patch or ring) (WHO (opens in a new tab)) can make periods lighter, shorter and more regular, or stop them when taken continuously, which can ease pain (NICHD (opens in a new tab)).
- Progestins — a pill, shot or hormonal (levonorgestrel) IUD (NICHD (opens in a new tab), WHO (opens in a new tab)). ESHRE strongly recommends progestins, including the levonorgestrel IUD, to reduce endometriosis pain (ESHRE guideline, 2022 (opens in a new tab)).
- GnRH agonists (shot or nasal spray) cause a temporary menopause-like state; side effects include hot flashes and bone loss, so they are used for limited periods (NICHD (opens in a new tab)), and ESHRE advises considering “add-back” hormones alongside them (ESHRE guideline, 2022 (opens in a new tab)).
- GnRH antagonists are pills that lower estrogen (Orilissa label (opens in a new tab)). Two carry FDA-approved labeling for moderate to severe endometriosis pain: elagolix (Orilissa) (FDA label via DailyMed (opens in a new tab), NICHD (opens in a new tab)) and relugolix combination therapy with estradiol and norethindrone acetate (Myfembree) (FDA label via DailyMed (opens in a new tab)). Use is time-limited because of bone loss that may not fully reverse; the labels also warn about mood changes, and Myfembree carries a boxed warning about blood clots (Orilissa label (opens in a new tab), Myfembree label (opens in a new tab)). ESHRE suggests GnRH medicines as second-line options (ESHRE guideline, 2022 (opens in a new tab)).
Surgery
- Laparoscopic surgery removes lesions by cutting them out (excision) or destroys them with heat or a laser (ablation) (NICHD (opens in a new tab)); ESHRE says surgeons may consider excision over ablation (ESHRE guideline, 2022 (opens in a new tab)). Most people have pain relief in the short term, but pain often returns (NICHD (opens in a new tab)); hormone treatment is often restarted afterward unless you are trying to get pregnant (Office on Women’s Health (opens in a new tab)).
- Hysterectomy, with or without removing the ovaries, may be an option for severe pain that hasn’t responded to other treatment in people who don’t want future pregnancies (WHO (opens in a new tab), ESHRE guideline, 2022 (opens in a new tab)). It is not always a cure; symptoms can remain or return (WHO (opens in a new tab), NICHD (opens in a new tab)).
Fertility treatment
Surgery and assisted reproduction such as IVF are covered in Endometriosis and fertility below.
Pelvic floor physical therapy
Pelvic floor muscle problems can add to chronic pelvic pain, and WHO says pain care that includes physiotherapy and cognitive behavioral therapy can reduce pain and improve quality of life (WHO (opens in a new tab)). A 2026 review of 7 studies found physiotherapy reduced endometriosis pain (Can et al., 2026 (opens in a new tab)), though ESHRE judged the evidence too uncertain to recommend specific non-medical treatments (ESHRE guideline, 2022 (opens in a new tab)). Ask for a pelvic health physical therapist.
What it costs
Medicine, imaging, surgery, physical therapy and IVF costs: cost estimate being researched.
Approach 2 of 6
Chiropractic
Chiropractic care has no role in treating endometriosis. Spinal adjustments cannot remove, shrink or stop endometriosis lesions on the pelvic organs.
- We searched PubMed for chiropractic care and endometriosis and read every result: none tested chiropractic treatment for endometriosis.
- A Cochrane review found no evidence that spinal manipulation helps primary or secondary period pain (Cochrane review, 2006 (opens in a new tab)), and a 2021 review of non-musculoskeletal conditions, including menstrual cramps, found no clear benefit (NCCIH (opens in a new tab)).
- The Office on Women’s Health notes that some women report pain relief with chiropractic care (Office on Women’s Health (opens in a new tab)), but reports are not the same as tested benefit.
- Low back and pelvic pain can itself be an endometriosis symptom (Office on Women’s Health (opens in a new tab)). If back pain worsens around your period, see a gynecology provider.
Approach 3 of 6
Acupuncture
Acupuncture is among the most-studied complementary treatments for endometriosis pain. The results are encouraging but limited, and it does not remove lesions.
- Cochrane review (2011): only one small trial met its standards, so the evidence was judged limited (Cochrane review, 2011 (opens in a new tab)).
- Largest sham-controlled trial (2023, China): in 106 women, 12 weeks of acupuncture eased period pain and improved quality of life more than sham acupuncture, but the difference had faded 12 weeks after treatment ended, and it didn’t help other pelvic pain or pain with sex. No severe side effects were reported (Li et al., 2023 (opens in a new tab)).
- Australian research: a small 2021 feasibility trial in Sydney found acupuncture acceptable and well tolerated (Armour et al., 2021 (opens in a new tab)), and a 2023 review of 6 trials (331 people) found less pelvic pain, mostly on low-certainty evidence (Giese et al., 2023 (opens in a new tab)).
- ESHRE made no recommendation for acupuncture because its benefits and harms are unclear (ESHRE guideline, 2022 (opens in a new tab)).
Safety and cost
Few complications have been reported, mostly from non-sterile needles or poor technique; most states license acupuncturists (NCCIH (opens in a new tab)). Private sessions run about $125–$230 for a first visit and $90–$185 for follow-ups; community clinics about $50–$90 (The Pricer (opens in a new tab)). Trials used many sessions, so check your coverage first.
Approach 4 of 6
Herbal medicine
No herb or supplement has been shown to treat endometriosis, and ESHRE made no recommendation for Chinese medicine or nutrition-based treatments (ESHRE guideline, 2022 (opens in a new tab)).
- Chinese herbal medicine: a Cochrane review found only two Chinese trials (158 women), neither against placebo. Herbs after surgery seemed about as helpful as a hormone drug, with fewer side effects, but more rigorous research is needed (Cochrane review, 2012 (opens in a new tab)).
- Supplements: a 2025 analysis of 9 placebo-controlled trials found supplements no better than placebo for endometriosis pain (Salmeri et al., 2025 (opens in a new tab)). Some women report relief with cinnamon twig, licorice root, thiamine, magnesium or omega-3s (Office on Women’s Health (opens in a new tab)), but reports are not the same as tested benefit.
- Turmeric: not proven for any condition, and its NCCIH page doesn’t address endometriosis. “High-absorption” curcumin products have been linked to liver damage, and turmeric supplements may be unsafe in pregnancy (NCCIH (opens in a new tab)).
- Licorice root can cause serious heart problems, especially in large amounts or with high blood pressure or heart or kidney disease (NCCIH (opens in a new tab)).
Hormonal effects and interactions
St. John’s wort can weaken birth control pills, a common endometriosis treatment (NCCIH (opens in a new tab)). Chamomile might have estrogen-like effects and reduce the effect of birth control pills (NCCIH (opens in a new tab)). Chasteberry may not be safe with hormone-sensitive conditions such as breast, uterine or ovarian cancer (NCCIH (opens in a new tab)).
Trying to conceive?
St. John’s wort, chasteberry and turmeric supplements may be unsafe in pregnancy (NCCIH (opens in a new tab), NCCIH (opens in a new tab), NCCIH (opens in a new tab)), and no non-medical approach has been shown to improve fertility in endometriosis (ESHRE guideline, 2022 (opens in a new tab)). Don’t use herbs while trying to conceive or during fertility treatment without your care team’s advice, and tell every provider what you take — supplements aren’t FDA-approved before sale (NCCIH (opens in a new tab)).
Approach 5 of 6
Massage therapy
Massage won’t remove endometriosis, but it may ease tension and help you relax. The NHS suggests massaging your tummy and back to help ease period pain (NHS (opens in a new tab)). The research is small:
- A 2010 study of 23 women, without a comparison group, reported less period pain after massage (Valiani et al., 2010 (opens in a new tab)).
- A 2024 trial of 44 women found 4 weeks of hydrotherapy plus Swedish massage eased period pain and pain with sex, but not overall quality of life (Rodríguez-Ruiz et al., 2024 (opens in a new tab)).
- A 2023 trial of 41 women found a physical therapist’s hands-on manual therapy program reduced pain more than a placebo treatment (Muñoz-Gómez et al., 2023 (opens in a new tab)).
Rare serious problems such as blood clots or nerve injury have been reported, some with vigorous massage (NCCIH (opens in a new tab)); tell your therapist about your endometriosis and any recent surgery. At one national chain, memberships run about $70–$90 a month for one 60-minute session (The Pricer (opens in a new tab)).
Approach 6 of 6
MBHA Wellness Coach
An MBHA Wellness Coach can help you build habits that make endometriosis easier to live with, alongside — never instead of — your medical care.
Keep a pain diary
Track when and where pain happens, how bad it is, and how it relates to your period, bowel movements, urination and sex, plus how heavily you bleed. A diary hasn’t been proven to speed diagnosis, but it can help you describe and show your symptoms (ESHRE guideline, 2022 (opens in a new tab)).
Heat, exercise and sleep
- A warm bath, or a heating pad on your belly (NHS (opens in a new tab), MedlinePlus (opens in a new tab)).
- Regular gentle exercise, such as walking, swimming, cycling or yoga (NHS (opens in a new tab), MedlinePlus (opens in a new tab)).
- Enough rest, plus relaxation such as meditation or yoga (MedlinePlus (opens in a new tab)).
Anti-inflammatory eating: what we know
Evidence is still weak. A 2024 review of 11 trials found most reported less pain, but the studies were small and at moderate or high risk of bias, and the best-designed ones showed no clear benefit (Meneghetti et al., 2024 (opens in a new tab)). Studies of omega-3-rich or gluten-free eating reported less pain, but most weren’t randomized (Sverrisdóttir et al., 2022 (opens in a new tab)), and evidence for a low-FODMAP diet comes from only three small studies (Rabelo et al., 2026 (opens in a new tab)). A balanced diet rich in fruits and vegetables, with little alcohol, is a sensible general goal (ESHRE guideline, 2022 (opens in a new tab)); a coach can help you test one change at a time.
Preparing for appointments
Bring your diary and your top questions. Before surgery, ask exactly what is planned — some procedures can’t be reversed and some affect fertility (NICHD (opens in a new tab)) — and, if treatment isn’t working or symptoms are very severe, ask about a specialist endometriosis service (NHS (opens in a new tab)).
Mental health and support
Endometriosis can affect mental health, including depression and anxiety (WHO (opens in a new tab)), and ESHRE advises clinicians to consider psychological support (ESHRE guideline, 2022 (opens in a new tab)). GnRH antagonist labels advise seeking medical attention for new or worse depression or anxiety (Orilissa label (opens in a new tab), Myfembree label (opens in a new tab)). See our Depression and Anxiety guides; in a crisis, call or text 988 (988 Lifeline (opens in a new tab)). Support groups can help too (WHO (opens in a new tab)), including the Endometriosis Foundation of America (opens in a new tab) and the Endometriosis Association (opens in a new tab), which offers peer support for women and teens.
Another approach
Endometriosis and fertility
Many women with endometriosis get pregnant, but it can be harder (Office on Women’s Health (opens in a new tab)); as many as 25–50% of women with infertility have endometriosis (WHO (opens in a new tab)). Growths and scar tissue can block the fallopian tubes or change the shape of the pelvis and reproductive organs, making it harder for sperm to find the egg (Office on Women’s Health (opens in a new tab)).
- Hormone-suppressing medicines don’t improve fertility; they prevent ovulation and delay pregnancy (NICHD (opens in a new tab)).
- Surgery may improve pregnancy chances in mild endometriosis, though by how much is unclear; repeated surgery on ovarian cysts may reduce how well the ovaries work (NICHD (opens in a new tab)).
- Fertility treatment includes ovulation induction, intrauterine insemination and IVF (WHO (opens in a new tab)). Assisted reproduction such as IVF doesn’t appear to increase the chance of endometriosis coming back (ESHRE guideline, 2022 (opens in a new tab)).
- Pregnancy is not a treatment; it doesn’t always improve symptoms (ESHRE guideline, 2022 (opens in a new tab)).
If you have endometriosis and are having trouble getting pregnant, talk to your doctor (Office on Women’s Health (opens in a new tab)). Our Pregnancy guide, coming soon, will cover more.
Another approach
Teens and period pain
More than half of people who have periods get some pain around their period (Office on Women’s Health (opens in a new tab)), but pain that is severe or worse than usual and not helped by painkillers, or that stops you doing your usual activities, needs a doctor’s attention (NHS (opens in a new tab)). Period pain caused by a condition such as endometriosis often gets worse over time (MedlinePlus (opens in a new tab)), and endometriosis can start from a girl’s first period (WHO (opens in a new tab), NHS (opens in a new tab)).
Signs worth raising: missing school because of period pain or needing birth control to manage it; pelvic pain between periods; pain with bowel movements or urination; and a family history of endometriosis (ESHRE guideline, 2022 (opens in a new tab)). Heavy periods and blood clots larger than a quarter matter too (Office on Women’s Health (opens in a new tab)).
What to expect: questions about symptoms and periods, and possibly a pelvic exam or an ultrasound or other imaging test (MedlinePlus (opens in a new tab)). An internal exam should be discussed with the teen and caregiver first, and if a scan through the vagina isn’t appropriate, an MRI or a scan through the belly or perineum may be considered (ESHRE guideline, 2022 (opens in a new tab)). Treatment usually starts with pain relievers or hormones such as birth control pills or a hormonal IUD; if scans are normal and these don’t help, laparoscopy may be considered (ESHRE guideline, 2022 (opens in a new tab)).
Self-care: regular gentle exercise, a heating pad or warm bath, enough rest, and relaxation such as yoga (NHS (opens in a new tab), MedlinePlus (opens in a new tab)). Parents: if your teen often misses school for period pain, take it seriously and bring a pain diary to the visit.
Member stories
Living with Endometriosis? Share your experience
Real experiences help others choose. Tell us what you tried — conventional medicine, chiropractic, acupuncture, herbs, massage or coaching — what it cost and what changed.
Sources
- NICHD — About endometriosis (opens in a new tab)
- NICHD — What are the symptoms of endometriosis? (opens in a new tab)
- NICHD — How do healthcare providers diagnose endometriosis? (opens in a new tab)
- NICHD — What are the treatments for endometriosis? (opens in a new tab)
- NICHD — What are the risk factors for endometriosis? (opens in a new tab)
- Office on Women’s Health — Endometriosis (updated 2025) (opens in a new tab)
- Office on Women’s Health — Ovarian cysts (opens in a new tab)
- Office on Women’s Health — Period problems (opens in a new tab)
- NHS — Endometriosis (reviewed 2024) (opens in a new tab)
- NHS — Adenomyosis (reviewed 2026) (opens in a new tab)
- NHS — Period pain (reviewed 2026) (opens in a new tab)
- NHS — Ectopic pregnancy (opens in a new tab)
- MedlinePlus — Ectopic pregnancy (health topic) (opens in a new tab)
- MedlinePlus — Period pain (health topic) (opens in a new tab)
- World Health Organization — Endometriosis (fact sheet) (opens in a new tab)
- Becker et al. — ESHRE guideline: endometriosis, Human Reproduction Open, 2022 (opens in a new tab)
- DailyMed — Orilissa (elagolix) prescribing information (opens in a new tab)
- DailyMed — Myfembree (relugolix, estradiol and norethindrone acetate) prescribing information (opens in a new tab)
- Can et al. — Physiotherapy for endometriosis-associated pelvic pain: systematic review and meta-analysis, Pain Medicine, 2026 (opens in a new tab)
- Proctor et al. — Spinal manipulation for primary and secondary dysmenorrhoea, Cochrane Database of Systematic Reviews, 2006 (opens in a new tab)
- NCCIH — Spinal manipulation: what you need to know (opens in a new tab)
- Zhu et al. — Acupuncture for pain in endometriosis, Cochrane Database of Systematic Reviews, 2011 (opens in a new tab)
- Li et al. — Efficacy of acupuncture for endometriosis-associated pain: a multicenter randomized placebo-controlled trial, Fertility and Sterility, 2023 (opens in a new tab)
- Armour et al. — Manual acupuncture plus usual care versus usual care alone for endometriosis-related chronic pelvic pain: a feasibility study, J Altern Complement Med, 2021 (opens in a new tab)
- Giese et al. — Acupuncture for endometriosis: a systematic review and meta-analysis, Integrative Medicine Research, 2023 (opens in a new tab)
- NCCIH — Acupuncture: effectiveness and safety (opens in a new tab)
- Flower et al. — Chinese herbal medicine for endometriosis, Cochrane Database of Systematic Reviews, 2012 (opens in a new tab)
- Salmeri et al. — Dietary supplements for endometriosis-associated pain: systematic review and meta-analysis of placebo-controlled trials, Gynecol Obstet Invest, 2025 (opens in a new tab)
- NCCIH — Turmeric (opens in a new tab)
- NCCIH — Licorice root (opens in a new tab)
- NCCIH — St. John’s wort (opens in a new tab)
- NCCIH — Chasteberry (opens in a new tab)
- NCCIH — Herb-drug interactions: what the science says (opens in a new tab)
- Valiani et al. — The effects of massage therapy on dysmenorrhea caused by endometriosis, Iran J Nurs Midwifery Res, 2010 (opens in a new tab)
- Rodríguez-Ruiz et al. — Hydrotherapy and Swedish massage for endometriosis-related chronic pelvic pain: a randomized controlled trial, Medicina, 2024 (opens in a new tab)
- Muñoz-Gómez et al. — A manual therapy protocol in women with pelvic pain due to endometriosis: a randomized clinical trial, J Clin Med, 2023 (opens in a new tab)
- NCCIH — Massage therapy: what you need to know (opens in a new tab)
- Meneghetti et al. — Effect of dietary interventions on endometriosis: systematic review and meta-analysis of randomized trials, Reproductive Sciences, 2024 (opens in a new tab)
- Sverrisdóttir et al. — Impact of diet on pain perception in women with endometriosis: a systematic review, Eur J Obstet Gynecol Reprod Biol, 2022 (opens in a new tab)
- Rabelo et al. — Effects of a low-FODMAP diet on symptoms and quality of life in women with endometriosis: systematic review and meta-analysis, J Hum Nutr Diet, 2026 (opens in a new tab)
- 988 Suicide & Crisis Lifeline (opens in a new tab)
- Endometriosis Foundation of America (opens in a new tab)
- Endometriosis Association (opens in a new tab)
- The Pricer — Acupuncture cost (updated 2026) (opens in a new tab)
- The Pricer — Massage Envy cost (updated 2026) (opens in a new tab)
This page is for education only and is not medical advice. Costs are typical U.S. ranges and estimates; yours will depend on your provider, location and insurance. Talk with your doctor before starting, stopping or combining any treatment. In an emergency, call 911. See our disclaimer.
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